Biomaterial Database

Effect of a cyclic hexapeptide analog (L363,586) of somatostatin on the function of pancreas grafts in dogs. 1985

T Liu, and D E Sutherland, and P L Chinn, and J S Najarian

Complications related to the exocrine secretions cause some pancreas grafts to fail in the early postoperative period. Somatostatin inhibits exocrine secretion, as well as insulin and glucagon release. L363,586 is a cyclic hexapeptide analog of somatostatin that is 50 to 100 times more potent than the native hormone in inhibiting islet hormone release. In a preliminary experiment in which permanent fistulas were created in two dogs, we demonstrated that L363,586 (0.3 micrograms/kg/60 min) results in a fourfold decrease in pancreatic exocrine secretion when measured for 210 min following a beef meal. In a separate experiment, five totally pancreatectomized dogs who received segmental pancreas autografts with pancreaticoductocystostomy 10 months previously had L363,586 (0.3 micrograms/kg/hr) administered by the Alzet osmotic pump subcutaneously for 7 days. Mean (+/-SE) daily serum amylase activity (IU/dl) during the week before the implant was 78 +/- 3, during the week of infusion was 65 +/- 2 (P less than 0.001), and during the week afterward was 76 +/- 2. In a prospective experiment, 12 totally pancreatectomized dogs received segmental pancreas autografts with anastomosis of the graft vessels to the iliac vessels and of the pancreatic duct to the bladder. L363,586 was administered by osmotic pump for 7 days to seven dogs at a dose of 0.3 micrograms/kg/hr. Mean (+/-SE) daily serum amylase levels at 1, 2, and 3 weeks posttransplant were 223 +/- 17, 81 +/- 3, and 82 +/- 5 in the L363,586-treated dogs and 229 +/- 18, 108 +/- 5, and 90 +/- 5 in the five untreated dogs (P less than 0.001 at 2 weeks).(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D010179	Pancreas	A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010189	Pancreatic Juice	The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.	Juice, Pancreatic,Juices, Pancreatic,Pancreatic Juices
D010456	Peptides, Cyclic	Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).	Circular Peptide,Cyclic Peptide,Cyclic Peptides,Cyclopeptide,Orbitide,Circular Peptides,Cyclopeptides,Orbitides,Peptide, Circular,Peptide, Cyclic,Peptides, Circular
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006728	Hormones	Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.	Hormone,Hormone Receptor Agonists,Agonists, Hormone Receptor,Receptor Agonists, Hormone
D000681	Amylases	A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.	Diastase,Amylase
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012636	Secretory Rate	The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.	Rate, Secretory,Rates, Secretory,Secretory Rates