Metabolic evaluation of urolithiasis and obesity in a midwestern pediatric population. 2014

John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
Medical College of Wisconsin, Milwaukee, Wisconsin.

OBJECTIVE The incidence of urolithiasis has been proved to be increasing in the adult population, and evidence to date suggests that the same holds true for the pediatric population. While adult urolithiasis is clearly linked to obesity, studies of pediatric patients have been less conclusive. We hypothesized that a population of otherwise healthy children with stones would have an increased body mass index compared to a control population, and that obese pediatric stone formers would have results on metabolic assessment that are distinct from nonobese stone formers. METHODS We retrospectively reviewed the charts of all patients 10 to 17 years old with upper tract urolithiasis without comorbidities treated between 2006 and 2011. Mean body mass index of our population was compared to state data, and 24-hour urine collection results were compared between obese and nonobese patients with stones. RESULTS The obesity rate in 117 patients with urolithiasis did not differ significantly from the obesity rate derived from the 2007 National Survey of Children's Health (observed/expected ratio 1.11, 95% CI 0.54-1.95). Using t-test and chi-square comparisons, overall 24-hour urine collection data did not show statistically significant differences. CONCLUSIONS Our results do not confirm obesity as a risk factor for pediatric urolithiasis in otherwise healthy patients. We also found no substantial metabolic differences between healthy nonobese stone formers and obese patients. While the pediatric literature is mixed, our study supports the majority of published series that have failed to establish a link between pediatric urolithiasis and obesity.

UI MeSH Term Description Entries
D008297 Male Males
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D014922 Wisconsin State bounded on the north by Lake Superior and Michigan, on the east by Lake Michigan, on the south by Illinois and Iowa, and on the west by Minnesota and Iowa.
D015992 Body Mass Index An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI Quetelet Index,Quetelet's Index,Index, Body Mass,Index, Quetelet,Quetelets Index

Related Publications

John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
September 2006, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
January 2022, Investigative and clinical urology,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
April 2013, The Journal of urology,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
February 1990, The Urologic clinics of North America,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
July 1990, Journal of the Formosan Medical Association = Taiwan yi zhi,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
March 2005, Current opinion in urology,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
November 2012, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
January 1992, Pediatric nephrology (Berlin, Germany),
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
June 2009, Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie,
John T Roddy, and Anas I Ghousheh, and Melissa A Christensen, and Charles T Durkee
January 2018, Urology annals,
Copied contents to your clipboard!