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Acetaldehyde inhibited both amylase secretion induced by maximal concentrations (300 pM) of cholecystokinin octapeptide and the binding of radioiodinated cholecystokinin to receptors on isolated rat pancreatic acini. This inhibition was concentration dependent (10 mM to 1 M for amylase secretion and 100 mM to 1 M for binding). However, a correlation between the two inhibitory effects could not be obtained. Furthermore, the inhibitory effects were not reversible. Acetaldehyde did not alter the basal amylase secretion between 6 and 45 mM concentrations. However, 60, 100 and 300 mM acetaldehyde significantly decreased basal amylase secretion; no significant change in amylase secretion was observed at 600 mM and 1 M. Higher concentrations of acetaldehyde produced a 2- to 10-fold increase in basal amylase secretion. 51Cr release from prelabeled acini revealed no significant cell membrane damage between 10 and 600 mM acetaldehyde. These data suggest that acetaldehyde inhibition of cholecystokinin-induced amylase secretion is intracellularly mediated.
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
January 1988,
Pancreas,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
June 1983,
The American journal of physiology,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
April 1984,
The American journal of physiology,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
February 1999,
Endocrinology,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
April 1992,
Biochemical and biophysical research communications,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
March 1986,
Toxicology and applied pharmacology,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
April 1987,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
October 1985,
Life sciences,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
August 2002,
Pancreas,
H Sankaran, and
M B Lewin, and
A Wong, and
C W Deveney, and
M F Wendland, and
R M Leimgruber, and
M C Geokas
December 1994,
The Biochemical journal,
