Biomaterial Database

Autoimmune retinopathy associated with carcinoid tumour of the small bowel. 2014

Siddharth Ogra, and Dianne Sharp, and Helen Danesh-Meyer

Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address: s.ogra@auckland.ac.nz.

Cancer associated retinopathy (CAR) is an immune mediated paraneoplastic condition associated with vision loss. It has been associated with a variety of systemic malignancies. The primary clinical presentation is rapid, progressive vision loss. Rod and cone dysfunction can cause other associated symptoms, such as nyctalopia. Electrophysiological testing and detection of anti-retinal antibodies are used to confirm the diagnosis. To our knowledge we describe the first patient with CAR associated with a carcinoid tumour of the gastrointestinal system. Auto-antibodies against alpha enolase and carbonic anhydrase II were detected with western blotting. Electroretinogram findings were consistent with rod and cone dysfunction.

UI	MeSH Term	Description	Entries
D007414	Intestinal Neoplasms	Tumors or cancer of the INTESTINES.	Cancer of Intestines,Intestinal Cancer,Cancer of the Intestines,Intestines Cancer,Intestines Neoplasms,Neoplasms, Intestinal,Cancer, Intestinal,Cancer, Intestines,Cancers, Intestinal,Cancers, Intestines,Intestinal Cancers,Intestinal Neoplasm,Intestines Cancers,Intestines Neoplasm,Neoplasm, Intestinal,Neoplasm, Intestines,Neoplasms, Intestines
D008297	Male		Males
D002276	Carcinoid Tumor	A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)	Argentaffinoma,Carcinoid,Carcinoid, Goblet Cell,Argentaffinomas,Carcinoid Tumors,Carcinoids,Carcinoids, Goblet Cell,Goblet Cell Carcinoid,Goblet Cell Carcinoids,Tumor, Carcinoid,Tumors, Carcinoid
D004596	Electroretinography	Recording of electric potentials in the retina after stimulation by light.	Electroretinographies
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D001327	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D058609	Visual Field Tests	Method of measuring and mapping the scope of vision, from central to peripheral of each eye.	Automated Perimetry Exam,Campimetry,Perimetry,Tangent Screen Exam,Visual Field Exam,Automated Perimetry Exams,Campimetries,Exam, Automated Perimetry,Exam, Tangent Screen,Exam, Visual Field,Exams, Automated Perimetry,Exams, Tangent Screen,Exams, Visual Field,Field Exam, Visual,Field Exams, Visual,Field Test, Visual,Field Tests, Visual,Perimetries,Perimetry Exam, Automated,Perimetry Exams, Automated,Screen Exam, Tangent,Screen Exams, Tangent,Tangent Screen Exams,Test, Visual Field,Tests, Visual Field,Visual Field Exams,Visual Field Test
D059545	Paraneoplastic Syndromes, Ocular	Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions.	Bilateral Diffuse Uveal Melanocytic Proliferation, Paraneoplastic,Cancer-Associated Retinopathy,Melanoma-Associated Retinopathy,Paraneoplastic Diseases, Ocular,Paraneoplastic Melanocytic Proliferation,Cancer Associated Retinopathy,Cancer-Associated Retinopathies,Disease, Ocular Paraneoplastic,Diseases, Ocular Paraneoplastic,Melanocytic Proliferation, Paraneoplastic,Melanocytic Proliferations, Paraneoplastic,Melanoma Associated Retinopathy,Melanoma-Associated Retinopathies,Ocular Paraneoplastic Disease,Ocular Paraneoplastic Diseases,Ocular Paraneoplastic Syndrome,Ocular Paraneoplastic Syndromes,Paraneoplastic Disease, Ocular,Paraneoplastic Melanocytic Proliferations,Paraneoplastic Syndrome, Ocular,Retinopathies, Cancer-Associated,Retinopathies, Melanoma-Associated,Retinopathy, Cancer-Associated,Retinopathy, Melanoma-Associated,Syndrome, Ocular Paraneoplastic,Syndromes, Ocular Paraneoplastic
D017809	Fatal Outcome	Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.	Fatal Outcomes,Outcome, Fatal,Outcomes, Fatal