Biomaterial Database

[Diagnostic values of heart rate variability on unexplained syncope in children]. 2013

Li Chen, and Chun-Yu Zhang, and Jun-Bao Du

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

OBJECTIVE To investigate the diagnostic values of heart rate varibility (HRV) on unexplained syncope (UPS) in children. METHODS Forty-nine children with unexplained syncope underwent head-up tilt test (HUT) and Holter monitering, then the differences were analyzed between HUT positive children and HUT negative children. The receiver operating characteristic (ROC) curve was used to explore the diagnostic values of HRV. RESULTS Of the 49 patients, 32 (65.3%) were HUT positive. The diagnostic positive rate of HUT was 65.3%. The SDNNi, rMSSD, TP, ULF, VLF, LF and HF in the HUT positive group were significantly higher than those in the HUT negative group (P<0.05), respectively. There were no significant differences in SDNN, pNN50 and triangular index between the patients with different HUT outcomes (P>0.05). The ROC curve on the predictive values of SDNNi, rMSSD, TP, ULF, VLF, LF and HF showed that ULF, LF, and HF (12 947.00, 9 462.50, and 9 509.00) as cutting values produced both high sensitivity (75.0%, 68.8%, and 68.8%) and specificity (64.7%, 64.7%, and 64.7%) to predict the diagnostic values of HUT for diagnosing unexplained syncope. CONCLUSIONS ULF, LF and HF can be considered as indicators for diagnosing neurally-mediated syncope in children. ULF, LF, and HF (12 947.00, 9 462.50, and 9 509.00) taken as cutting values may produce both high sensitivity and specificity.

UI	MeSH Term	Description	Entries
D007024	Hypotension, Orthostatic	A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.	Hypotension, Postural,Orthostatic Hypotension,Postural Hypotension
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D005260	Female		Females
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D012372	ROC Curve	A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.	ROC Analysis,Receiver Operating Characteristic,Analysis, ROC,Analyses, ROC,Characteristic, Receiver Operating,Characteristics, Receiver Operating,Curve, ROC,Curves, ROC,ROC Analyses,ROC Curves,Receiver Operating Characteristics
D054972	Postural Orthostatic Tachycardia Syndrome	A syndrome of ORTHOSTATIC INTOLERANCE combined with excessive upright TACHYCARDIA, and usually without associated ORTHOSTATIC HYPOTENSION. All variants have in common an excessively reduced venous return to the heart (central HYPOVOLEMIA) while upright.	Postural Tachycardia Syndrome,Syndrome, Postural Tachycardia,Tachycardia Syndrome, Postural