BIOMAT Database Logo BIOMAT Database Logo

Acnegenicity testing in rabbits. An objective quantification method. 1985

E Bechgaard

An objective method for the quantification of follicular hyperkeratosis is proposed for the rabbit ear assay of acnegenicity. The area (area%) of hyperkeratinized follicles, covering a stereomicroscopic photo of the epidermis, is proposed for the quantification of the response. The uniformity of two observers' quantification was evaluated in six tested formulations. The quantification of the response in area% was found to be a suitable and objective alternative to visual scoring on a graded scale. The median relative difference between two observers' area%-quantification was found to be 26%, and there was no statistically significant difference between the two observers' quantification (p greater than 0.10). An area% of 2, 7, and 15 is preliminarily suggested to be equivalent to the lower limit for scores 1, 2 and 3 respectively.

UI MeSH Term Description Entries
D008297 Male Males
D009226 Myristates Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid. Tetradecanoates
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D004423 Ear The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE. Vestibulocochlear System,Vestibulocochlear Apparatus,Apparatus, Vestibulocochlear,Ears,System, Vestibulocochlear
D000152 Acne Vulgaris A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors. Acne
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

E Bechgaard
An objective testing method to determine driving ability.
January 1985, Acta oto-laryngologica,
E Bechgaard
Optical profilometry: an objective method for quantification of facial wrinkles.
September 1989, Journal of the American Academy of Dermatology,
E Bechgaard
An objective method to identify non-responders in neurovascular coupling testing.
July 2020, Journal of neuroscience methods,
E Bechgaard
[Objective method for the quantification of pain].
September 1987, Ugeskrift for laeger,
E Bechgaard
Ninhydrin test--an objective method for testing local anesthetic drugs.
January 1960, Acta anaesthesiologica Scandinavica,
E Bechgaard
[Method for testing analgesia in rabbits].
May 1957, Arzneimittel-Forschung,
E Bechgaard
An objective and reproducible method for quantification of aortic regurgitation after TAVI.
July 2014, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
E Bechgaard
[Rabbit ear model as an acnegenicity test. 1].
January 1985, Dermatologische Monatschrift,
E Bechgaard
The podigauge: an objective method of testing foot strength: preliminary report.
February 1958, Journal of the American Podiatry Association,
E Bechgaard
Objective quantification method for measuring in vivo accumulated dental plaque.
January 1975, Journal of dental research,
Copied contents to your clipboard!