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Bepridil is an anti-anginal agent with a novel chemical structure. Its main pharmacological effects are an increase in coronary blood flow, a reduction in myocardial oxygen demand, reduction in cardiac work, primarily by a decrease in after-load and a dose-dependent negative chronotropic effect, and anti-arrhythmic properties. These are mainly due to a calcium-antagonistic action. There is evidence that fast sodium channels in heart muscle are also inhibited. Trials have shown that bepridil is effective in the prophylactic treatment of various forms of angina pectoris and accompanying arrhythmias. Pharmacokinetic data justify once-daily administration. The evidence suggests that bepridil is generally well tolerated. This paper reviews already published studies and the results of recent investigations on the pharmacological and clinical efficacy of bepridil.
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
January 1972,
Bollettino della Societa italiana di cardiologia,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
November 1974,
L'union medicale du Canada,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
September 1983,
European heart journal,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
December 1981,
Annales de cardiologie et d'angeiologie,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
December 1969,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
January 1983,
Basic research in cardiology,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
January 1971,
The Medical letter on drugs and therapeutics,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
November 1972,
Minnesota medicine,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
October 1996,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
J S Alpert, and
P Coumel, and
K Greeff, and
D M Krikler, and
W J Remme, and
E Schönbaum, and
C W Verduyn
February 1964,
Journal of the South Carolina Medical Association,
