-transparent.png){kind=logo}
The effects of hepatic artery administration of degradable starch microspheres on liver energy charge and nucleic acid anabolism were studied in rats. Liver energy charge was evaluated 20 and 60 min after the injection of degradable starch microspheres. As compared to controls the microspheres had no effect on liver energy charge. The incorporation of orotic acid, uracil, and thymidine into liver RNA or DNA was studied 1 h after hepatic artery injection of precursor alone or together with degradable starch microspheres. Orotic acid and uracil incorporation into RNA was studied in normal rats and the DNA incorporation of thymidine in animals with regenerating livers. Orotic acid and thymidine were given in trace amounts. Uracil was given in amounts corresponding to a therapeutic dose of 5-fluorouracil. The addition of microspheres had no effects on the incorporation of the nucleic acid precursors into RNA or DNA. Thus, in the normal liver degradable starch microspheres administered by the hepatic artery had no influence on liver energy charge or RNA anabolism in the liver. Also the microspheres had no negative effects on the DNA anabolism in proliferating liver cells.
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
January 1990,
Selective cancer therapeutics,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
August 1989,
Gan to kagaku ryoho. Cancer & chemotherapy,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
July 2006,
World journal of gastroenterology,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
September 1967,
The Biochemical journal,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
December 1986,
The Journal of pharmacy and pharmacology,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
September 1985,
Cancer research,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
January 1986,
Cancer drug delivery,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
January 1994,
Acta oncologica (Stockholm, Sweden),
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
October 1985,
Chemical & pharmaceutical bulletin,
H Teder, and
P I Christensson, and
K F Aronsen, and
L Lewan, and
J Ljungberg, and
U Stenram
October 1962,
Experimental cell research,
