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Combinations of interferons (IFNs) and cytostatic drugs were studied in subrenal capsule assay (SRCA) using fresh human ovarian cancer samples. Slight tumour growth inhibition was observed with IFN-alpha and IFN-gamma. The effect was more pronounced if combination IFN-alpha + IFN-gamma was used. Cytostatic drug combination cyclophosphamide + cisplatin + doxorubicin (combination I) was more effective than interferons, and combination methotrexate + tegafur (combination II) was about equal to IFN-alpha. When IFN-alpha was given together with cytostatic drugs, the antitumour effect was diverse: both synergistic and antagonistic effects were found, as well as no evidence of interaction. IFNs did not increase the toxicity of cytostatic drugs. If there is a good correlation between SRCA and clinical results, the combination of IFNs and cytotoxic drugs should be used clinically in connection with a predictive test.
L Kangas, and
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M Grönroos, and
J Mäenpää, and
M Perilä
September 1986,
European journal of cancer & clinical oncology,
L Kangas, and
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January 1988,
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L Kangas, and
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September 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
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January 1985,
Annales chirurgiae et gynaecologiae. Supplementum,
L Kangas, and
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January 1985,
Annales chirurgiae et gynaecologiae. Supplementum,
L Kangas, and
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August 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
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L Kangas, and
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L Kangas, and
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March 1990,
Gan to kagaku ryoho. Cancer & chemotherapy,
L Kangas, and
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J Mäenpää, and
M Perilä
January 1985,
Annales chirurgiae et gynaecologiae. Supplementum,
