Ezrin expression is an independent prognostic factor in gastro-intestinal cancers. 2013

Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
Centre for Tumour Biology, John Vane Science Centre, Barts Cancer Institute-a CR-UK Centre of Excellence, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.

BACKGROUND Ezrin, a member of the ezrin-radixin-moesin (ERM) family of plasma membrane-cytoskeleton linker proteins, has been associated with metastatic behavior. METHODS Microarrayed pathological tissues of surgically resected colorectal cancer liver metastasis (CRLM) and whole tissue sections of cancer of the ampulla of Vater (CAV) were analyzed to determine ezrin expression levels and correlation with survival. The requirement of ezrin in invasive capability was assessed using in vitro assays. RESULTS Surgically resected CAV showing a low ezrin score have a better 5-year disease-specific survival than those showing a high ezrin score (P < 0.0001). Similarly, high ezrin expression at the invasive front of CRLM resulted in poor disease-free survival (P = 0.05). Multivariate analysis demonstrated high ezrin expression to be an independent adverse prognostic factor for CAV (hazard ratio (HR) 15.22 (95 % confidence interval (CI) 1.98-117.03), P < 0.01) and CRLM (HR 6.42 (95 % CI 1.01-52.43), P = 0.05), among other clinically relevant variables such as lymph node metastasis (for CAV) and the presence of extrahepatic disease, large hepatic metastases (>5 cm), and close surgical resection margins (<5 mm) (all for CRLM). In vitro experiments indicated that ezrin expression was vital for cellular processes such as adhesive and invasive activity. CONCLUSIONS High ezrin expression indicates an adverse prognosis in primary CAV and CRLM.

UI MeSH Term Description Entries
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D003138 Common Bile Duct Neoplasms Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
D003598 Cytoskeletal Proteins Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible. Proteins, Cytoskeletal
D005770 Gastrointestinal Neoplasms Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL. Gastrointestinal Cancer,Cancer of Gastrointestinal Tract,Cancer of the Gastrointestinal Tract,Neoplasms, Gastrointestinal,Cancer, Gastrointestinal,Cancers, Gastrointestinal,Gastrointestinal Cancers,Gastrointestinal Neoplasm,Gastrointestinal Tract Cancer,Gastrointestinal Tract Cancers,Neoplasm, Gastrointestinal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014670 Ampulla of Vater A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla. Duodenal Papilla, Major,Vater's Ampulla,Greater Duodenal Papilla,Hepatopancreatic Ampulla,Ampulla, Hepatopancreatic,Ampulla, Vater's,Ampullas, Hepatopancreatic,Duodenal Papilla, Greater,Duodenal Papillas, Greater,Greater Duodenal Papillas,Hepatopancreatic Ampullas,Major Duodenal Papilla,Vater Ampulla,Vaters Ampulla
D015153 Blotting, Western Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. Immunoblotting, Western,Western Blotting,Western Immunoblotting,Blot, Western,Immunoblot, Western,Western Blot,Western Immunoblot,Blots, Western,Blottings, Western,Immunoblots, Western,Immunoblottings, Western,Western Blots,Western Blottings,Western Immunoblots,Western Immunoblottings
D015999 Multivariate Analysis A set of techniques used when variation in several variables are studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables. Analysis, Multivariate,Multivariate Analyses
D047468 Immunoprecipitation The aggregation of soluble ANTIGENS with ANTIBODIES, alone or with antibody binding factors such as ANTI-ANTIBODIES or STAPHYLOCOCCAL PROTEIN A, into complexes large enough to fall out of solution. Co-Immunoprecipitation,Immune Precipitation,Co Immunoprecipitation,Co-Immunoprecipitations,Immune Precipitations,Precipitation, Immune,Precipitations, Immune

Related Publications

Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
November 2020, Journal of cellular and molecular medicine,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
January 2016, Clinical cancer research : an official journal of the American Association for Cancer Research,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
May 2015, Oncoimmunology,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
August 2021, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
August 2011, Human pathology,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
November 2004, American journal of obstetrics and gynecology,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
January 2003, Anticancer research,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
December 2020, Cancers,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
January 2010, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists,
Prabhu Arumugam, and Stefano Partelli, and Stacey J Coleman, and Ivana Cataldo, and Stefania Beghelli, and Claudio Bassi, and Nilukushi Wijesuriya, and Jo-Anne Chin Aleong, and Fieke E M Froeling, and Aldo Scarpa, and Hemant M Kocher
April 2010, Human pathology,
Copied contents to your clipboard!