Biomaterial Database

Analysis of proteolytic enzymes and their natural inhibitors in serum and bronchial lavage fluid in atopic bronchial asthma, chronic bronchitis and pneumonia. 1985

T Płusa, and H Tchórzewski

The protease-antiprotease balance was evaluated in some respiratory tract diseases. Analysis of the protease activity and the natural inhibitors of proteolytic enzymes was carried out on 10 patients with atopic bronchial asthma, 21 with chronic bronchitis, 12 with pneumonia and 11 health volunteers. Paralelly, the inflammatory potency of bronchial lavage fluid was determined in guinea-pig skin test. In our studies of bronchial lavage fluids some selective changes of proteolytic enzyme activities were documented as follows: in pneumonia patients--the increase of acid and neutral proteases activity; in chronic bronchitis--the moderate increase of activities of all examined proteases and in atopic bronchial asthma--the increase of acid protease activity. Similarly, levels of the natural inhibitors of proteolytic enzymes were selectively elevated: alpha-1-antitrypsin in pneumonia and chronic bronchitis patients and alpha-2-macroglobulin in asthmatics. This finding may suggest that the proteolytic enzymes and their inhibitors play an important role in the respiratory tract pathology. This concept is supported by the high inflammatory response observed with bronchial lavage fluids obtained from pneumonia patients in guinea-pig skin test. The authors suggest that the determination of protease activity and level of the natural inhibitors of proteolytic enzymes in bronchial lavage fluids may be useful for clinical prognosis and pharmacological treatment.

UI	MeSH Term	Description	Entries
D007507	Therapeutic Irrigation	The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.	Douching,Lavage,Douchings,Irrigation, Therapeutic,Irrigations, Therapeutic,Lavages,Therapeutic Irrigations
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009961	Orosomucoid		Acid Seromucoid,Seromucoid,Serum Sialomucin,alpha 1-Acid Glycoprotein,alpha 1-Acid Seromucoid,A(1)-Acid Seromucoid,Acid alpha 1-Glycoprotein,Alpha(1)-Acid Glycoprotein,alpha 1-Acid Glycoprotein (Acute Phase),alpha 1-Glycoprotein Acid,Acid alpha 1 Glycoprotein,Glycoprotein, alpha 1-Acid,Seromucoid, Acid,Seromucoid, alpha 1-Acid,Sialomucin, Serum,alpha 1 Acid Glycoprotein,alpha 1 Acid Seromucoid,alpha 1 Glycoprotein Acid
D010447	Peptide Hydrolases	Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.	Peptidase,Peptidases,Peptide Hydrolase,Protease,Proteases,Proteinase,Proteinases,Proteolytic Enzyme,Proteolytic Enzymes,Esteroproteases,Enzyme, Proteolytic,Hydrolase, Peptide
D011014	Pneumonia	Infection of the lung often accompanied by inflammation.	Experimental Lung Inflammation,Lobar Pneumonia,Lung Inflammation,Pneumonia, Lobar,Pneumonitis,Pulmonary Inflammation,Experimental Lung Inflammations,Inflammation, Experimental Lung,Inflammation, Lung,Inflammation, Pulmonary,Inflammations, Lung,Inflammations, Pulmonary,Lobar Pneumonias,Lung Inflammation, Experimental,Lung Inflammations,Lung Inflammations, Experimental,Pneumonias,Pneumonias, Lobar,Pneumonitides,Pulmonary Inflammations
D001991	Bronchitis	Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	Bronchitides
D004791	Enzyme Inhibitors	Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.	Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D005260	Female		Females
D006242	Haptoglobins	Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.	Haptoglobin