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Four human embryonal carcinoma (EC) cell lines (ITO, NEC 8, NEC 14, NEC 15) derived independently from testicular germ-cell tumors were established in vitro. In their xenografted tumor tissues, all of them exhibited histological characteristics consistent with EC. The cell-biological characterization of these human EC cell lines was investigated with reference to well-known murine EC cell lines. This included examination of their morphology, growth, tumorigenic potential, karyotype, cell-aggregate formation, HLA expression, large glycopeptides, AFP and HCG production, plasminogen-activator secretion, and LDH profiles. Three (ITO, NEC 14, NEC 15) of these human EC cell lines shared cell-biological characteristics consistent with typical EC, but one of them (NEC 8) differed from the others with respect to its rapid growth, high tumorigenic potential, formation of solid cell aggregates, and less differentiated, solid histological pattern. Thus, it is suggested that there are several developmentally different types of human EC cells. The relationship between the properties of these human EC cell lines and their differentiation potential is discussed.
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
May 1986,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
July 1986,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
November 2004,
Oncogene,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
September 2005,
Oncogene,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
July 2007,
The American journal of surgical pathology,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
January 2021,
Methods in molecular biology (Clifton, N.J.),
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
June 2018,
Cell reports,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
September 1982,
In vitro,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
August 2014,
Der Radiologe,
S Sekiya, and
M Kawata, and
H Iwasawa, and
N Inaba, and
M Sugita, and
N Suzuki, and
T Motoyama, and
T Yamamoto, and
H Takamizawa
August 1991,
Laboratory investigation; a journal of technical methods and pathology,
