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The modulation by the interferon (IFN) inducers poly I:C and Newcastle disease virus (NDV) of the effector phase of adjuvant-enhanced delayed-type hypersensitivity (DH) was studied in mice. A strongly enhanced DH was induced in mice to ultraviolet (UV) light inactivated Semliki forest virus (SFV) by the use of the adjuvant dimethyldioctadecylammonium bromide. At day 6 after intracutaneous immunization, DH was elicited with SFV and measured 24 and 48 h later as increase in footpad thickness (footpad swelling test). Systemic, intravenous administration of either poly I:C, UV-inactivated NDV, or NDV-induced IFN prior to elicitation of DH with antigen resulted in a temporarily suppressed DH reaction. Both the poor swelling at 3 h and strong swelling at 24 h were suppressed, while the swelling at 48 h was enhanced. The model described provides a sensitive in vivo method to study modulating effects of drugs and microbial agents on the effector phase of DH.
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
May 1983,
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C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
June 1984,
Cellular immunology,
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
November 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
October 1972,
Canadian journal of microbiology,
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
May 1975,
Proceedings of the National Academy of Sciences of the United States of America,
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
May 1972,
Medicine,
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
October 1973,
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C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
June 1998,
Immunology,
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
November 2015,
Thrombosis and haemostasis,
C A Kraaijeveld, and
W Kamphuis, and
B J Benaissa-Trouw, and
M Harmsen, and
H Snippe
January 1970,
Archivum immunologiae et therapiae experimentalis,
