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Basement membrane collagen is relatively rich in hydroxylysine and the glycosides of hydroxylysine, glucosylgalactosylhydroxylysine and galactosylhydroxylysine. In this paper a modified procedure for analysis of these substances in urine is described, using a purification-step with the cation-exchange resin Amberlite CG-120 type II and a modified program for amino acid analysis. Values are obtained from 75 healthy persons of different ages ranging from prematurity to adulthood. The influence of maturation is studied. Prematures and young children have a high and rather variable excretion of all components, whereas adults have low and similar excretion rates. Neither the ratio glucosylgalactosylhydroxylysine/galactosylhydroxylysine nor the percentage of glycosylated hydroxylysine can be shown to be age-dependent. These data are important for the study of collagen disorders, especially in childhood.
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
June 1994,
Biological & pharmaceutical bulletin,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
May 1977,
The Journal of clinical investigation,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
February 1975,
Clinica chimica acta; international journal of clinical chemistry,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
January 1987,
Nephron,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
August 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
January 1979,
Laboratornoe delo,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
March 1979,
Clinica chimica acta; international journal of clinical chemistry,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
January 1976,
Problemy endokrinologii,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
May 1986,
Ultrasound in medicine & biology,
C H Schröder, and
J P Langeveld, and
B H van Raay-Selten, and
F J Trijbels, and
R de Graaf, and
J H Veerkamp, and
L A Monnens
January 1985,
Revista chilena de pediatria,
