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The control of immunoglobulin class switching appears to involve T cell-derived lymphokines. Such lymphokines have been shown to affect isotype expression in polyclonally activated B cells. We show in this paper that the same lymphokines similarly control isotype expression in an antigen-specific response acting in concert with a "T cell independent" antigen. In this situation, B cell growth factor II (BCGF II) enhances the production of antigen-specific IgM antibodies, whereas the production of antigen-specific IgG1 antibodies is only observed in the presence of B cell differentiation factor gamma (BCDF gamma). These results suggest that these lymphokines (and perhaps additional ones) are involved in the control of isotype expression in antigen-specific responses.
H Tesch, and
W Müller, and
K Rajewsky
February 2020,
Cytokine,
H Tesch, and
W Müller, and
K Rajewsky
January 2001,
Journal of clinical microbiology,
H Tesch, and
W Müller, and
K Rajewsky
January 1978,
Contemporary topics in immunobiology,
H Tesch, and
W Müller, and
K Rajewsky
January 1982,
Immunological reviews,
H Tesch, and
W Müller, and
K Rajewsky
October 2005,
Veterinary immunology and immunopathology,
H Tesch, and
W Müller, and
K Rajewsky
March 1988,
Immunology letters,
H Tesch, and
W Müller, and
K Rajewsky
June 1989,
Journal of autoimmunity,
H Tesch, and
W Müller, and
K Rajewsky
July 1993,
Journal of immunology (Baltimore, Md. : 1950),
H Tesch, and
W Müller, and
K Rajewsky
July 1988,
Zeitschrift fur Gastroenterologie,
H Tesch, and
W Müller, and
K Rajewsky
November 1998,
Veterinary parasitology,
