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Effects of noxious electrical tooth stimulations and intraarterial administration of bradykinin or inhalation of volatile anesthetics on substance P content in the diencephalon-mesencephalon, pons-medulla and the spinal cord were examined in the rat. Noxious stimulation by electrical long duration stimulation (type 2) of tooth pulp caused an increase of substance P content in the ponsmedulla. Inhalation of volatile anesthetics such as methoxyflurane and diethylether produced an increase of substance P content in the spinal cord; and in addition, methoxyflurane produced a decrease of substance P content in ponsmedulla. However, halothane did not produce any changes in substance P content in any parts of the central nervous system (CNS). These results suggest that volatile anesthetics such as diethyl-ether and methoxyflurane act on the substance P neuron and may modulate pain transmission through the action of substance P in the pons-medulla or the spinal cord.
Y Kotani, and
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T Shibutani, and
H Matsuura, and
R Inoki
January 1969,
Acta anaesthesiologica Scandinavica. Supplementum,
Y Kotani, and
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R Inoki
January 1983,
Nature,
Y Kotani, and
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R Inoki
October 1977,
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Y Kotani, and
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January 1981,
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Y Kotani, and
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R Inoki
January 1953,
Research publications - Association for Research in Nervous and Mental Disease,
Y Kotani, and
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Anesthesiology,
Y Kotani, and
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T Shibutani, and
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R Inoki
January 1991,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
Y Kotani, and
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H Matsuura, and
R Inoki
December 1988,
Pharmaceutical research,
Y Kotani, and
Y Hirota, and
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T Shibutani, and
H Matsuura, and
R Inoki
January 1984,
Peptides,
Y Kotani, and
Y Hirota, and
K Sugiyama, and
S Joh, and
T Shibutani, and
H Matsuura, and
R Inoki
September 1981,
Naunyn-Schmiedeberg's archives of pharmacology,
