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Normal human peripheral blood lymphocytes were tested for their susceptibility to infection with retroviruses isolated from patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Of 10 normal individuals tested, lymphocytes from all subjects became infected and produced virus as detected by assay for Mg+2-dependent reverse transcriptase. Lymphocytes from different individuals were demonstrated to be either high or low producers of reverse transcriptase after infection. The kinetics of virus production were similar in cells from both high- and low-producing individuals. A significant correlation was observed between high and low viral-producing lymphocytes and expression of the Leu-3/T4 (CD4) surface molecule. Mitogen-stimulated peripheral blood lymphocytes exposed to HTLV-III/LAV manifested productive viral infection, as reflected by the appearance of early syncytia, followed by reverse transcriptase. Unstimulated peripheral blood lymphocyte cultures displayed late syncytia but no detectable reverse transcriptase upon exposure to virus. The addition of anti-human interferon-alpha did not appear to have an appreciable effect on viral production in normal peripheral blood lymphocytes exposed to the virus.
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
January 1986,
Nordisk medicin,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
October 1986,
Indiana medicine : the journal of the Indiana State Medical Association,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
July 1986,
Quintessenz Journal,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
January 1986,
Pennsylvania medicine,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
November 1986,
Archives of neurology,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
January 1986,
Pathologica,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
October 1986,
Deutsche medizinische Wochenschrift (1946),
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
January 1985,
Lancet (London, England),
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
January 1987,
Medicina clinica,
T Folks, and
J Kelly, and
S Benn, and
A Kinter, and
J Justement, and
J Gold, and
R Redfield, and
K W Sell, and
A S Fauci
May 1986,
JAMA,
