-transparent.png){kind=logo}
The treatment of K-562 cells with 10(-5) M to 10(-7) M 5-azacytidine induced a marked increase in benzidine-positive cells. Similarly, the exposure of K-562 cells to 2 X 10(-3) M butyric acid or 5 X 10(-7) M 1-beta-arabinofuranosylcytosine or 1 X 10(-3) M hydroxyurea induced an erythroid differentiation of K-562 cells. The activity of DNA-methyltransferase and the level of methylcytosine in newly synthesized DNA were significantly decreased when the cells were treated with 5-azacytidine or butyric acid, while 1-beta-arabinofuranosylcytosine or hydroxyurea had no inhibitory effect on DNA-methylation of K-562 cells. These results suggest that the inhibition of DNA-methylation is not necessarily a specific phenomenon for erythroid differentiation of K-562 cells.
R Sasaki, and
Y Miura
June 1984,
Cell differentiation,
R Sasaki, and
Y Miura
January 1985,
Eksperimental'naia onkologiia,
R Sasaki, and
Y Miura
July 1989,
Journal of chemotherapy (Florence, Italy),
R Sasaki, and
Y Miura
February 1983,
Cancer research,
R Sasaki, and
Y Miura
November 1992,
Experimental cell research,
R Sasaki, and
Y Miura
May 1990,
Biochemical and biophysical research communications,
R Sasaki, and
Y Miura
October 1995,
Cellular immunology,
R Sasaki, and
Y Miura
April 1980,
The Journal of biological chemistry,
R Sasaki, and
Y Miura
November 1990,
Proceedings of the National Academy of Sciences of the United States of America,
R Sasaki, and
Y Miura
May 1984,
Cell biology international reports,
