Isoquinoline alkaloids from cell suspension cultures of Fumaria capreolata. 1985

T Tanahashi, and M H Zenk
Lehrstuhl für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-8000, München 2, FRG.

Fumaria capreolata was taken into cell suspension culture. The culture yielded a biomass of about 12 g dry weight per liter of medium; the dried cells contained ca. 0.1% of alkaloids. Besides choline, the following ten known isoquinoline alkaloids were isolated from the cell extract in crystalline form: coptisine, dehydrocheilanthifoline; (+)-isoboldine; magnoflorine; N-methylcoclaurine; (+)-reticuline; (-)-pallidine; protopine; sanguinarine; (-)-scoulerine. This is the most diverse isoquinoline alkaloid spectrum thus far published for a cell suspension culture.

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