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The properties of human pulmonary mast cells obtained by enzymic dispersion of whole lung and by bronchoalveolar lavage (BAL) have been compared with those of the basophil leucocyte. The latter cell types responded with release of histamine to challenge with anti-human IgE but the dispersed cells reacted only after passive sensitisation with serum from an atopic donor. Disodium cromoglycate inhibited the release of histamine from both types of pulmonary mast cell although the characteristics of the inhibition were different in the two cases. The drug was ineffective against the basophil. Increased numbers of mast cells were recovered by lavage of asthmatic subjects and these cells responded to immunological challenge with an enhanced release of histamine. The possible clinical significance of these findings in human bronchial asthma is discussed.
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
January 1988,
Allergie und Immunologie,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
June 1982,
Canadian Medical Association journal,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
April 1999,
Clinical science (London, England : 1979),
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
March 1986,
Clinical allergy,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
June 1994,
Agents and actions,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
August 1997,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
January 1990,
International archives of allergy and applied immunology,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
September 1989,
The American review of respiratory disease,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
March 1986,
The American review of respiratory disease,
K B Leung, and
K C Flint, and
J Brostoff, and
B N Hudspith, and
N M Johnson, and
F L Pearce
July 1993,
Pneumologie (Stuttgart, Germany),
