OBJECTIVE To evaluate the effect of two gutta percha solvents on the bond strength of two resin-based sealers to root canal dentin. METHODS Root canals of extracted single rooted human mandibular premolars (n = 60) were decoronated and instrumented with a rotary NiTi system to an apical size of 40 and randomly divided into three groups (n = 20) based on the chemical treatment: Group I, saline (control); group II, Xylene and group III, Endosolv E. All groups were divided into two sub-groups (n = 10) based on the root filling material: sub-group A, epoxy resin sealer (AH Plus); sub-group B, methacrylate resin sealer (Epiphany). Roots were then sectioned and push-out tests were performed. The data was analysed using two-way analysis of variance (ANOVA) and a multiple comparison test (p = 0.05). RESULTS There was a significant difference in bond strength of both sealers between the control and test groups (p < 0.05). The bond strength of the epoxy resin sealer (sub-group A) in group II was significantly lower than in group III (p < 0.05). However, there was no significant difference between groups II and III for the methacrylate resin sealer (sub-group b) (p > 0.05). CONCLUSIONS Gutta Percha solvents had an adverse effect on bond strengths of resin sealers to root canal dentin. This was dependent on the chemistry of the solvent and the sealer.