Cytotoxic ent-kaurane diterpenoids from Salvia cavaleriei. 2013

Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, People's Republic of China.

Fifteen new ent-kaurane diterpenoids, compounds 1-15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu Kα radiation. Compounds 1-15 were evaluated for their cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line. Compounds 1-10, 12, 14, and 15 showed broad-spectrum cytotoxicity, with compounds 1, 3, 6-10, 12, and 15 exhibiting more potent cytotoxicity than the positive control, cis-platin, with IC50 values ranging from 0.65 to 6.4 μM.

UI MeSH Term Description Entries
D008968 Molecular Conformation The characteristic three-dimensional shape of a molecule. Molecular Configuration,3D Molecular Structure,Configuration, Molecular,Molecular Structure, Three Dimensional,Three Dimensional Molecular Structure,3D Molecular Structures,Configurations, Molecular,Conformation, Molecular,Conformations, Molecular,Molecular Configurations,Molecular Conformations,Molecular Structure, 3D,Molecular Structures, 3D,Structure, 3D Molecular,Structures, 3D Molecular
D002942 Circular Dichroism A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Circular Dichroism, Vibrational,Dichroism, Circular,Vibrational Circular Dichroism
D002945 Cisplatin An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. Platinum Diamminodichloride,cis-Diamminedichloroplatinum(II),cis-Dichlorodiammineplatinum(II),Biocisplatinum,Dichlorodiammineplatinum,NSC-119875,Platidiam,Platino,Platinol,cis-Diamminedichloroplatinum,cis-Platinum,Diamminodichloride, Platinum,cis Diamminedichloroplatinum,cis Platinum
D004354 Drug Screening Assays, Antitumor Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals. Anticancer Drug Sensitivity Tests,Antitumor Drug Screens,Cancer Drug Tests,Drug Screening Tests, Tumor-Specific,Dye Exclusion Assays, Antitumor,Anti-Cancer Drug Screens,Antitumor Drug Screening Assays,Tumor-Specific Drug Screening Tests,Anti Cancer Drug Screens,Anti-Cancer Drug Screen,Antitumor Drug Screen,Cancer Drug Test,Drug Screen, Anti-Cancer,Drug Screen, Antitumor,Drug Screening Tests, Tumor Specific,Drug Screens, Anti-Cancer,Drug Screens, Antitumor,Drug Test, Cancer,Drug Tests, Cancer,Screen, Anti-Cancer Drug,Screen, Antitumor Drug,Screens, Anti-Cancer Drug,Screens, Antitumor Drug,Test, Cancer Drug,Tests, Cancer Drug,Tumor Specific Drug Screening Tests
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000972 Antineoplastic Agents, Phytogenic Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. Antineoplastics, Botanical,Antineoplastics, Phytogenic,Agents, Phytogenic Antineoplastic,Botanical Antineoplastics,Phytogenic Antineoplastic Agents,Phytogenic Antineoplastics
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D045786 Diterpenes, Kaurane A group of DITERPENES cyclized into four rings. Ent-Kaurane,Ent-Kaurene,Kaurane,Kaurane Diterpenoid,Kaurane Diterpenoids,Ent-Kauranes,Ent-Kaurenes,Kauranes,Diterpenoid, Kaurane,Diterpenoids, Kaurane,Ent Kaurane,Ent Kaurene,Kaurane Diterpenes

Related Publications

Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
April 2014, Journal of natural products,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
January 2011, Chemical & pharmaceutical bulletin,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
January 2009, Planta medica,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
October 2002, Planta medica,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
August 2013, Chemistry & biodiversity,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
August 2009, Journal of Asian natural products research,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
December 2005, Chemistry & biodiversity,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
January 2009, Phytochemistry,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
October 2022, Chemistry & biodiversity,
Heng Zheng, and Qiong Chen, and Mengke Zhang, and Yongji Lai, and Liang Lei, and Penghua Shu, and Jinwen Zhang, and Yongbo Xue, and Zengwei Luo, and Yan Li, and Guangmin Yao, and Yonghui Zhang
June 2002, Planta medica,
Copied contents to your clipboard!