Epigenetic effects of green tea polyphenols in cancer. 2013

Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, 900 Veteran Avenue, Warren Hall 14-166, Los Angeles, CA 90095, USA.

Epigenetics describes heritable alterations of gene expression and chromatin organization without changes in DNA sequence. Both hypermethylation and hypomethylation of DNA can affect gene expression and the multistep process of carcinogenesis. Epigenetic changes are reversible and may be targeted by dietary interventions. Bioactive compounds from green tea (GT) such as (-)-epigallocatechin gallate have been shown to alter DNA methyltransferase activity in studies of esophageal, oral, skin, Tregs, lung, breast and prostate cancer cells, which may contribute to the chemopreventive effect of GT. Three out of four mouse model studies have confirmed the inhibitory effect of (-)-epigallocatechin gallate on DNA methylation. A human study demonstrated that decreased methylation of CDX2 and BMP-2 in gastric carcinoma was associated with higher GT consumption. It is the goal of this review to summarize our current knowledge of the potential of GT to alter epigenetic processes, which may be useful in chemoprevention.

UI MeSH Term Description Entries
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002392 Catechin An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms. Catechinic Acid,Catechuic Acid,(+)-Catechin,(+)-Cyanidanol,(+)-Cyanidanol-3,(-)-Epicatechin,(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol,2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-,3,3',4',5,7-Flavanpentol,Catergen,Cianidanol,Cyanidanol-3,Epicatechin,KB-53,Z 7300,Zyma,Cyanidanol 3,KB 53,KB53
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071616 CDX2 Transcription Factor An antennapedia-like homeodomain transcription factor that regulates the expression of multiple genes in the INTESTINAL MUCOSA. It plays a critical role in many processes from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. CDX2 Protein,Caudal Type Homeo Box 2 Protein,Caudal Type Homeo Box Transcription Factor 2,Caudal Type Homeobox Transcription Factor 2,Cdx-2 Protein,Cdx-2-3 Protein,Cdx-3 Protein,Homeobox Protein CDX-2,Homeobox Protein CDX2,Transcription Factor CDX2,CDX-2, Homeobox Protein,CDX2, Homeobox Protein,CDX2, Transcription Factor,Cdx 2 3 Protein,Cdx 2 Protein,Cdx 3 Protein,Homeobox Protein CDX 2
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013662 Tea The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE. Black Tea,Green Tea,Black Teas,Green Teas,Tea, Black,Tea, Green,Teas, Black,Teas, Green
D015534 Trans-Activators Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins. Nuclear Trans-Acting Factor,Trans-Acting Factors,Trans-Acting Factor,Trans-Activator,Transactivator,Transactivators,Factor, Nuclear Trans-Acting,Factor, Trans-Acting,Factors, Trans-Acting,Nuclear Trans Acting Factor,Trans Acting Factor,Trans Acting Factors,Trans Activator,Trans Activators,Trans-Acting Factor, Nuclear
D015972 Gene Expression Regulation, Neoplastic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. Neoplastic Gene Expression Regulation,Regulation of Gene Expression, Neoplastic,Regulation, Gene Expression, Neoplastic
D044127 Epigenesis, Genetic A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression. Epigenetic Processes,Epigenetic Process,Epigenetics Processes,Genetic Epigenesis,Process, Epigenetic,Processes, Epigenetic,Processes, Epigenetics

Related Publications

Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
September 2004, Frontiers in bioscience : a journal and virtual library,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
January 2019, Molecules (Basel, Switzerland),
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
June 2021, Molecules (Basel, Switzerland),
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
February 2007, Photodermatology, photoimmunology & photomedicine,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
November 2004, The Journal of nutrition,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
January 2018, Journal of natural science, biology, and medicine,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
January 2013, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
October 2008, Cancer letters,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
January 2007, Frontiers in bioscience : a journal and virtual library,
Susanne M Henning, and Piwen Wang, and Catherine L Carpenter, and David Heber
June 2015, Molecular carcinogenesis,
Copied contents to your clipboard!