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The effect of calcium antagonists on basophil activation was investigated in 14 subjects. Verapamil, methoxyverapamil and diltiazem, in a concentration range of 1-100 microM, exert a concentration-dependent inhibition on the human basophil histamine release induced by calcium ionophore A23187, zymosan activated human serum and grass pollen allergens. This inhibitory effect is highly variable from subject to subject and from drug to drug. At concentrations higher than 200 microM, verapamil, methoxyverapamil and diltiazem induce a calcium independent histamine secretion from basophil leukocytes. This mediator release is associated with an increase in LDH levels in the cell supernatant and seems to be due to a cytotoxic effect.
A Miadonna, and
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M Lorini, and
M Froldi, and
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October 1981,
Biochemical pharmacology,
A Miadonna, and
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E Leggieri, and
M Lorini, and
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August 1987,
Allergy,
A Miadonna, and
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E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
May 1983,
Allergy,
A Miadonna, and
A Tedeschi, and
E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
January 1984,
Arzneimittel-Forschung,
A Miadonna, and
A Tedeschi, and
E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
December 1984,
Infection and immunity,
A Miadonna, and
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E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
April 1990,
Agents and actions,
A Miadonna, and
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E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
September 1986,
Life sciences,
A Miadonna, and
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E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
May 1985,
Nihon Kyobu Shikkan Gakkai zasshi,
A Miadonna, and
A Tedeschi, and
E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
August 1979,
Allergy,
A Miadonna, and
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E Leggieri, and
M Lorini, and
M Froldi, and
C Zanussi
August 1985,
Nihon Kyobu Shikkan Gakkai zasshi,
