Giant serpentine aneurysms have recently been successfully treated with endovascular parent artery occlusion with or without distal by-pass. This report retrospectively analyses the outcome of endovascular parent artery occlusion for intracranial giant serpentine aneurysms. Medical records and cerebral angiograms from our endovascular center were analyzed retrospectively. Five patients with serpentine aneurysms were treated by endovascular occlusion of the parent artery at the site of the aneurysm. These patients had selective treatment. The clinical and angiographic outcomes in five patients were assessed at three months to three years. No cerebral infarction occurred. Of the patients, five made excellent recoveries at follow-up. No recurrence or rebleeding was noted. Endovascular parent artery occlusion may be a safe and effective way to treat intracranial giant serpentine aneurysms.