Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion. 2013

Natalia C Rodrigues, and Lívia Assis, and Kelly R Fernandes, and Angela Magri, and Daniel A Ribeiro, and Roberta Brunelli, and Daniela C C Abreu, and Ana Claudia M Renno
Department of Physiotherapy, Federal University of São Carlos, São Carlos, São Paulo, Brazil.

The aim of this study was to evaluate the effects of 660 nm low-level laser therapy (LLLT) on muscle regeneration after cryolesion in rat tibialis anterior muscle. Sixty-three Wistar rats were divided into a control group, 10 J/cm(2) laser-treated group, and 50 J/cm(2) laser-treated group. Each group formed three subgroups (n = 7 per group), and the animals were sacrificed 7, 14, or 21 d after lesion. Histopathological findings revealed a lower inflammatory process in the laser-treated groups after 7 d. After 14 d, irradiated animals at both fluences showed higher granulation tissue, new muscle fibers, and organized muscle structure. After 21 d, full tissue repair was observed in all groups. Moreover, irradiated animals at both fluences showed smaller necrosis area in the first experimental period evaluated. MyoD immunoexpression was observed in both treated groups 7 d postinjury. Myogenin immunoexpression was detected after 7 and 14 d. The higher fluence increased the number of blood vessels after 14 and 21 d. These results suggest that LLLT, at both fluences, positively affects injured skeletal muscle in rats, accelerating the muscle-regeneration process.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D008297 Male Males
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D006097 Granulation Tissue A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells. Granulation Tissues,Tissue, Granulation,Tissues, Granulation
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D017570 MyoD Protein A myogenic regulatory factor that controls myogenesis. Though it is not clear how its function differs from the other myogenic regulatory factors, MyoD appears to be related to fusion and terminal differentiation of the muscle cell. MyoD Factor,Factor, MyoD,Protein, MyoD
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D054023 Lasers, Semiconductor Lasers with a semiconductor diode as the active medium. Diode lasers transform electric energy to light using the same principle as a light-emitting diode (LED), but with internal reflection capability, thus forming a resonator where a stimulated light can reflect back and forth, allowing only a certain wavelength to be emitted. The emission of a given device is determined by the active compound used (e.g., gallium arsenide crystals doped with aluminum or indium). Typical wavelengths are 810, 1,060 and 1,300 nm. (From UMDNS, 2005) Diode Lasers,Gallium Aluminum Arsenide Lasers,Gallium Arsenide Lasers,GaAlAs Lasers,GaAs Lasers,Lasers, GaAlAs,Lasers, GaAs,Lasers, Gallium Aluminum Arsenide,Lasers, Gallium Arsenide,Lasers, Quantum Cascade,Quantum Cascade Lasers,Semiconductor Diode Lasers,Arsenide Laser, Gallium,Arsenide Lasers, Gallium,Diode Laser,Diode Laser, Semiconductor,Diode Lasers, Semiconductor,GaAlAs Laser,GaAs Laser,Gallium Arsenide Laser,Laser, Diode,Laser, GaAlAs,Laser, GaAs,Laser, Gallium Arsenide,Laser, Quantum Cascade,Laser, Semiconductor,Laser, Semiconductor Diode,Lasers, Diode,Lasers, Semiconductor Diode,Quantum Cascade Laser,Semiconductor Diode Laser,Semiconductor Laser,Semiconductor Lasers

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