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No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. 2014
Wasim Khan, and
Vincent Giampietro, and
Cedric Ginestet, and
Flavio Dell'Acqua, and
David Bouls, and
Steven Newhouse, and
Richard Dobson, and
Tobias Banaschewski, and
Gareth J Barker, and
Arun L W Bokde, and
Christian Büchel, and
Patricia Conrod, and
Herta Flor, and
Vincent Frouin, and
Hugh Garavan, and
Penny Gowland, and
Anreas Heinz, and
Bernd Ittermann, and
Hervé Lemaître, and
Frauke Nees, and
Tomas Paus, and
Zdenka Pausova, and
Marcella Rietschel, and
Michael N Smolka, and
Andreas Ströhle, and
Jean Gallinat, and
Eric Westman, and
Gunther Schumann, and
Simon Lovestone, and
Andrew Simmons, and
King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.
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