-transparent.png){kind=logo}
Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick's disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer's disease. In all of these conditions the ballooned neurons contain phosphorylated epitopes recognized by monoclonal antibodies to neurofilaments, but not epitopes unique to Alzheimer neurofibrillary tangles and Pick bodies. The morphological features and immunohistochemical properties of ballooned neurons in these disorders bear resemblance to swollen neurons produced by neurotoxins that impair axoplasmic transport of neurofilaments. This finding, by analogy, suggests that impaired axoplasmic transport of neurofilaments may be a common mechanism in various dementing neurodegenerative diseases.
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
August 1992,
Neuropathology and applied neurobiology,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
November 1986,
Journal of neurology, neurosurgery, and psychiatry,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
January 1990,
Acta neuropathologica,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
December 1991,
Chinese medical journal,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
May 1990,
Journal of neuropathology and experimental neurology,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
March 2022,
Equine veterinary journal,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
December 2004,
Cellular and molecular life sciences : CMLS,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
December 1988,
Brain research,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
January 1990,
Acta neuropathologica,
D W Dickson, and
S H Yen, and
K I Suzuki, and
P Davies, and
J H Garcia, and
A Hirano
June 1998,
Cellular and molecular biology (Noisy-le-Grand, France),
