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The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo. Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produced significant protection against adriamycin-mediated acute and chronic cardiotoxicity in mice. N-acetylcysteine, a free radical scavenger, successfully used in the prevention of the cardiomyopathy, was also found to be an inhibitor of histamine release induced by adriamycin and compound 48/80 on rat peritoneal cells. This study further supports the hypothesis that the release of histamine may be involved in the pathogenesis of anthracycline cardiotoxicity.
F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
January 2012,
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F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
January 2007,
Cell biology and toxicology,
F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
January 2000,
Nihon rinsho. Japanese journal of clinical medicine,
F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
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F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
March 1988,
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F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
May 1980,
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F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
January 1974,
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F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
January 1982,
Giornale italiano di cardiologia,
F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
May 1980,
American heart journal,
F B Klugmann, and
G Decorti, and
L Candussio, and
V Grill, and
F Mallardi, and
L Baldini
January 1984,
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