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The histogenesis of Ewing sarcoma is still controversial; we therefore studied the expression of intermediate filaments (IF) in cell lines derived from Ewing tumors since identification of IF in tumor cells is considered a reliable marker of tissue origin and differentiation. All nine lines studied expressed vimentin IF; in addition, a small number of Ewing cells from three lines expressed keratin filaments. After treatment with phorbol esters, a high percentage of cells from these three lines synthesize keratin IF identified by immunoblotting as keratin 8 and 18 polypeptides, which are expressed by single epithelia and epithelial cells in early embryonic development. Furthermore cells from a fourth line synthesize keratins after transplantation in nude mice. These data indicate that, under certain conditions, undifferentiated Ewing cells may acquire an IF phenotype related to that of epithelial cells.
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
July 1987,
International journal of cancer,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
February 1986,
Journal of cutaneous pathology,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
January 1985,
Virchows Archiv. A, Pathological anatomy and histopathology,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
January 1993,
Pathobiology : journal of immunopathology, molecular and cellular biology,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
January 1999,
Neoplasma,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
October 1983,
Laboratory investigation; a journal of technical methods and pathology,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
January 1987,
Current topics in pathology. Ergebnisse der Pathologie,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
April 1984,
The Journal of cell biology,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
November 1980,
Biochimica et biophysica acta,
K Dellagi, and
M Lipinski, and
D Paulin, and
M M Portier, and
G M Lenoir, and
J C Brouet
January 1982,
Methods in cell biology,
