-transparent.png){kind=logo}
The metabolism of L-tryptophan (TRP) before and after an oral loading dose of 20 mg/kg body weight was studied in three patients with actinic reticuloid (AR) and four healthy male volunteers. The preload mean plasma TRP concentrations and mean 24-hour urinary excretions of TRP in the AR group were significantly lower than in the control group. After oral TRP administration, plasma TRP concentrations increased normally in AR, thereby excluding defective intestinal absorption. The mean preload and postload excretions of kynurenic acid (KA), xanthurenic acid (XA), 5-hydroxyindoleacetic acid (5HIAA), and 3-indoleacetic acid (3IAA) were not significantly different between the two groups. We conclude that KA, which has been shown to have phototoxic properties in vitro, is not altered primarily in AR, and that the reported abnormalities of TRP metabolism are most likely the consequence of the severe photosensitivity in this disorder.
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
January 1964,
Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
July 1968,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
January 1963,
Annales paediatrici. International review of pediatrics,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
January 1971,
Pediatrics,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
January 1973,
Acta dermato-venereologica,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
January 1979,
Journal of nutritional science and vitaminology,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
April 1950,
Bollettino della Societa italiana di biologia sperimentale,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
April 1965,
Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
September 1982,
Archives of dermatology,
E C Vonderheid, and
E L Sobel, and
R D Hoeldtke, and
G J Faerber, and
V S Sardi
January 1971,
Indian journal of dermatology and venereology,
