BIOMAT Database Logo BIOMAT Database Logo

Levels of 25 cytokines in the first seven days of life in newborn infants. 2013

Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
Department of Pediatrics, Harapan Kita Women and Children Hospital, Jakarta, Indonesia. setyadewi13@yahoo.com.

BACKGROUND Novel methods for cytokine analysis allow for the simultaneous measurement of 25 cytokines in 50 μL serum or plasma. Data on values of most of these cytokines in non-infected newborn infants are lacking. We analyzed levels of 25 cytokines in the first week of life in non-infected preterm and term infants and related them to gestational age. RESULTS During the first week after birth, no trend over time was found in any of the cytokines, except for IL-1Ra and IL-6 where higher values were found in the first four hours. Between 24 and 72 hrs levels of IL-1Ra, IL-2, IL-8, IL-12, IL-13, IL-15, IL-17, IFNγ, MIP-1a, MCP-1, TNFα were lower in infants born after 30-32 wks compared to infants ≥ 36 wks; levels of IL-6, IL-10, IP-10 were lower in preterm infants of both 30-32 and 33-36 weeks. No difference between groups for any of the levels was found for IL-1b, IL-2r, IL-4, IL-5, IL-7, IFNa, MIP-1b, GM-CSF, Eotaxin and RANTES. CONCLUSIONS Levels of 25 interleukines are stable in the first week of life in non-infected infants. Infants born after 30-32 wks showed lower levels of fourteen cytokines compared to infants born after more then 36 wks. This indicates a lower stimulation or activation of Th-1 cells, monocytes and dendritic cells in these infants.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007234 Infant, Premature A human infant born before 37 weeks of GESTATION. Neonatal Prematurity,Premature Infants,Preterm Infants,Infant, Preterm,Infants, Premature,Infants, Preterm,Premature Infant,Prematurity, Neonatal,Preterm Infant
D008297 Male Males
D009000 Monocytes Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles. Monocyte
D003713 Dendritic Cells Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION). Dendritic Cells, Interdigitating,Interdigitating Cells,Plasmacytoid Dendritic Cells,Veiled Cells,Dendritic Cells, Interstitial,Dendritic Cells, Plasmacytoid,Interdigitating Dendritic Cells,Interstitial Dendritic Cells,Cell, Dendritic,Cell, Interdigitating,Cell, Interdigitating Dendritic,Cell, Interstitial Dendritic,Cell, Plasmacytoid Dendritic,Cell, Veiled,Cells, Dendritic,Cells, Interdigitating,Cells, Interdigitating Dendritic,Cells, Interstitial Dendritic,Cells, Plasmacytoid Dendritic,Cells, Veiled,Dendritic Cell,Dendritic Cell, Interdigitating,Dendritic Cell, Interstitial,Dendritic Cell, Plasmacytoid,Interdigitating Cell,Interdigitating Dendritic Cell,Interstitial Dendritic Cell,Plasmacytoid Dendritic Cell,Veiled Cell
D005260 Female Females
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016207 Cytokines Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. Cytokine

Related Publications

Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
[Pneumonia in newborn infants during the first few days of life].
October 1956, Pediatria polska,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
[Skin changes in newborn infants in the first 5 days of life].
June 2000, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
[Central and peripheral hemodynamics in newborn infants in the first few days of life].
November 1981, Pediatriia,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
[Otoscopy and acoustic impedance in newborn infants in the first 5 days of life].
January 1982, Otolaryngologia polska = The Polish otolaryngology,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
Plasma ACTH values during the first seven days of life in infants of diabetic mothers.
December 1975, The Journal of pediatrics,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
[Variations in the amount of protein in newborn infants during the first days of life].
June 1952, Minerva ginecologica,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
Newborn emergencies: the first 30 days of life.
February 2006, Pediatric clinics of North America,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
Partial parenteral nutrition in preterm and newborn infants during the first three days of life.
January 1979, JPEN. Journal of parenteral and enteral nutrition,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
[Metabolic profile of newborn calves and levels of immunoglobulins in the first days of life].
July 1983, Veterinarni medicina,
Setyadewi Lusyati, and Christian V Hulzebos, and Jantien Zandvoort, and Pieter J J Sauer
Troponin-T levels in perinatally asphyxiated infants during the first 15 days of life.
November 2005, Acta paediatrica (Oslo, Norway : 1992),
Copied contents to your clipboard!