Biomaterial Database

Metabolism: DNA double-strand breaks and p53 activity in β-cell failure. 2014

Linda Koch

UI	MeSH Term	Description	Entries
D003924	Diabetes Mellitus, Type 2	A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D016159	Tumor Suppressor Protein p53	Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.	p53 Tumor Suppressor Protein,Cellular Tumor Antigen p53,Oncoprotein p53,TP53 Protein,TRP53 Protein,p53 Antigen,pp53 Phosphoprotein,Phosphoprotein, pp53
D044903	Congenital Hyperinsulinism	A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).	Persistent Hyperinsulinemia Hypoglycemia of Infancy,Familial Hyperinsulinemic Hypoglycemia 1,Familial Hyperinsulinism,Hyperinsulinemia Hypoglycemia of Infancy,Hyperinsulinemic Hypoglycemia Due to Focal Adenomatous Hyperplasia,Hyperinsulinemic Hypoglycemia, Familial, 1,Hyperinsulinemic Hypoglycemia, Familial, 2,Hyperinsulinemic Hypoglycemia, Persistent,Hyperinsulinism, Congenital,Hyperinsulinism, Familial,Hyperinsulinism, Neonatal,Hypoglycemia, Hyperinsulinemic, of Infancy,Infancy Hyperinsulinemia Hypoglycemia,Neonatal Hyperinsulinism,PHHI Hypoglycemia,Persistent Hyperinsulinemic Hypoglycemia,Congenital Hyperinsulinisms,Familial Hyperinsulinisms,Hyperinsulinemic Hypoglycemias, Persistent,Hyperinsulinisms, Congenital,Hyperinsulinisms, Familial,Hyperinsulinisms, Neonatal,Hypoglycemia, PHHI,Hypoglycemia, Persistent Hyperinsulinemic,Hypoglycemias, PHHI,Hypoglycemias, Persistent Hyperinsulinemic,Infancy Hyperinsulinemia Hypoglycemias,Neonatal Hyperinsulinisms,PHHI Hypoglycemias,Persistent Hyperinsulinemic Hypoglycemias
D050417	Insulin-Secreting Cells	A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.	Pancreatic beta Cells,beta Cells, Pancreatic,Pancreatic B Cells,B Cell, Pancreatic,B Cells, Pancreatic,Cell, Insulin-Secreting,Cells, Insulin-Secreting,Insulin Secreting Cells,Insulin-Secreting Cell,Pancreatic B Cell,Pancreatic beta Cell,beta Cell, Pancreatic
D053903	DNA Breaks, Double-Stranded	Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.	Double-Stranded DNA Breaks,Double-Strand DNA Breaks,Double-Stranded DNA Break,Break, Double-Strand DNA,Break, Double-Stranded DNA,Breaks, Double-Strand DNA,Breaks, Double-Stranded DNA,DNA Break, Double-Strand,DNA Break, Double-Stranded,DNA Breaks, Double Stranded,DNA Breaks, Double-Strand,Double Strand DNA Breaks,Double Stranded DNA Break,Double Stranded DNA Breaks,Double-Strand DNA Break