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The effect of systemically administrated cholecystokinin analog, caerulein, on monoaminergic neurons was examined in discrete regions of rat brain. A single injection of caerulein (400 micrograms/kg, i.p.) significantly elevated 5-hydroxyindoleacetic acid (5HIAA) levels in the prefrontal cortex lateral field, nucleus accumbens, tuberculum olfactorium and striatum after 2 hours, together with a significant increase in striatal serotonin (5HT). Moreover, the time-course study showed that the caerulein-induced increase in both 5HIAA and 5HT levels lasted even for 24 hours, and their levels tended to recover to the control values gradually. This time-dependent change was not found in the other monoamines and their metabolites. These results suggest a long-lasting action of caerulein on 5HT neurons in specific regions of rat brain.
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
December 1984,
Brain research,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
August 1991,
Brain research,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
August 1985,
Japanese journal of pharmacology,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
September 1989,
Neuropharmacology,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
January 1990,
Journal of neurochemistry,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
November 2012,
Oral diseases,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
January 1986,
General pharmacology,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
March 1979,
Nature,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
January 1990,
Journal of neurotrauma,
T Kuroki, and
T Matsumoto, and
M Hirano, and
H Kagoshima, and
H Yao, and
H Uchimura, and
K Nakamura, and
T Nakahara
February 1986,
European journal of pharmacology,
