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A method for the localization of rat pre-prosomatostatin mRNA by in situ hybridization with 32P- and 3H-labeled antisense RNA probes is reported. Somatostatin mRNA was detected in endocrine cells of the rat gut mucosa, pancreas and thyroid in a distribution identical to immunoreactive somatostatin. In addition, in situ hybridization allowed localization of reactive neurons in the submucous and myenteric plexus of the gut, sites which are variably positive or negative for immunoreactive somatostatin even after colchicine treatment. These studies indicate that in situ hybridization is more sensitive than immunohistochemistry in some instances for demonstration of somatostatin in gene expression.
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 1986,
The Histochemical journal,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 1985,
Journal of cellular biochemistry,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
June 1990,
Laboratory investigation; a journal of technical methods and pathology,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 2011,
Methods in cell biology,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 1992,
Nippon Ganka Gakkai zasshi,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 1991,
Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 1989,
Methods in enzymology,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
August 1994,
Histochemistry,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
January 2006,
Methods in molecular medicine,
H Höfler, and
H Childers, and
M R Montminy, and
R H Goodman, and
R M Lechan, and
R A DeLellis, and
A S Tischler, and
H J Wolfe
September 1993,
Hearing research,
