Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. 2014

Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia E-mail : hildahafez@hotmail.com.

BACKGROUND Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to phenolic compounds like oleuropein. Although oleuropein has anticancer activity, the underlying mechanisms of action remain unknown. The study aimed to assess the mechanism of oleuropin-induced breast cancer cell apoptosis. METHODS p53, Bcl-2 and Bax gene expression was evaluated by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) in luminal MCF-7 cells. RESULTS Oleuropein-induced apoptosis was accompanied by up-regulation of both p53 and Bax gene expression levels and down-regulation in Bcl2. CONCLUSIONS Oleuropein induces apoptosis in breast tumour cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of the p53 pathway.

UI MeSH Term Description Entries
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000959 Antihypertensive Agents Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. Anti-Hypertensive,Anti-Hypertensive Agent,Anti-Hypertensive Drug,Antihypertensive,Antihypertensive Agent,Antihypertensive Drug,Anti-Hypertensive Agents,Anti-Hypertensive Drugs,Anti-Hypertensives,Antihypertensive Drugs,Antihypertensives,Agent, Anti-Hypertensive,Agent, Antihypertensive,Agents, Anti-Hypertensive,Agents, Antihypertensive,Anti Hypertensive,Anti Hypertensive Agent,Anti Hypertensive Agents,Anti Hypertensive Drug,Anti Hypertensive Drugs,Anti Hypertensives,Drug, Anti-Hypertensive,Drug, Antihypertensive,Drugs, Anti-Hypertensive,Drugs, Antihypertensive
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D014407 Tumor Cells, Cultured Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured
D015153 Blotting, Western Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. Immunoblotting, Western,Western Blotting,Western Immunoblotting,Blot, Western,Immunoblot, Western,Western Blot,Western Immunoblot,Blots, Western,Blottings, Western,Immunoblots, Western,Immunoblottings, Western,Western Blots,Western Blottings,Western Immunoblots,Western Immunoblottings
D015972 Gene Expression Regulation, Neoplastic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. Neoplastic Gene Expression Regulation,Regulation of Gene Expression, Neoplastic,Regulation, Gene Expression, Neoplastic
D016159 Tumor Suppressor Protein p53 Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. p53 Tumor Suppressor Protein,Cellular Tumor Antigen p53,Oncoprotein p53,TP53 Protein,TRP53 Protein,p53 Antigen,pp53 Phosphoprotein,Phosphoprotein, pp53
D049109 Cell Proliferation All of the processes involved in increasing CELL NUMBER including CELL DIVISION. Cell Growth in Number,Cellular Proliferation,Cell Multiplication,Cell Number Growth,Growth, Cell Number,Multiplication, Cell,Number Growth, Cell,Proliferation, Cell,Proliferation, Cellular

Related Publications

Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
March 2019, Journal of cellular biochemistry,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
June 2013, Journal of cancer prevention,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
November 2021, Molecular biology reports,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
September 2023, Journal of complementary & integrative medicine,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
January 2022, Nutrition and cancer,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
October 2019, International journal of molecular sciences,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
April 2014, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
June 2016, Oncology reports,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
December 2015, Genetics and molecular research : GMR,
Zeinab Korany Hassan, and Maha Hussein Elamin, and Sawsan Ali Omer, and Maha Hassan Daghestani, and Ebtesam Salah Al-Olayan, and Mai Abdelrahman Elobeid, and Promy Virk
January 2014, Molecular medicine reports,
Copied contents to your clipboard!