BIOMAT Database Logo BIOMAT Database Logo

The HLA-Dw HAG specificity is defined by DR beta cDNA hybridization as a hybrid haplotype carrying DR5 and DRw6 determinants. 1987

M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart

The serological and cellular class II definition of HTC9W1802 HAG was difficult to establish. RFLP obtained with a DR beta cDNA probe indicated that HAG could be a hybrid haplotype composed of fragments characteristic for DR5 and DRw6 specificities.

UI MeSH Term Description Entries
D009693 Nucleic Acid Hybridization Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503) Genomic Hybridization,Acid Hybridization, Nucleic,Acid Hybridizations, Nucleic,Genomic Hybridizations,Hybridization, Genomic,Hybridization, Nucleic Acid,Hybridizations, Genomic,Hybridizations, Nucleic Acid,Nucleic Acid Hybridizations
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D006681 HLA-D Antigens Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology. Antigens, HLA-D,Class II Human Antigens,HLA-Dw Antigens,Human Class II Antigens,Ia-Like Antigens, Human,Immune Response-Associated Antigens, Human,Immune-Associated Antigens, Human,Immune-Response Antigens, Human,HLA-D,HLA-Dw,Immune Response Associated Antigens, Human,Antigens, HLA D,Antigens, HLA-Dw,Antigens, Human Ia-Like,Antigens, Human Immune-Associated,Antigens, Human Immune-Response,HLA D Antigens,HLA Dw Antigens,Human Ia-Like Antigens,Human Immune-Associated Antigens,Human Immune-Response Antigens,Ia Like Antigens, Human,Immune Associated Antigens, Human,Immune Response Antigens, Human
D006684 HLA-DR Antigens A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS. HLA-DR,Antigens, HLA-DR,HLA DR Antigens
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000939 Epitopes Sites on an antigen that interact with specific antibodies. Antigenic Determinant,Antigenic Determinants,Antigenic Specificity,Epitope,Determinant, Antigenic,Determinants, Antigenic,Specificity, Antigenic
D015805 HLA-DR5 Antigen A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*11 and DRB1*12 alleles. HLA-DR5,Antigen, HLA-DR5,HLA DR5 Antigen
D015808 HLA-DR6 Antigen A broad-specificity HLA-DR antigen that is associated with HLA-DRB1 CHAINS encoded by DRB1*13 and DRB1*14 alleles. HLA-DR6,Antigen, HLA-DR6,HLA DR6 Antigen

Related Publications

M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
HLA-DR2, -DR5, and DRw6 associated Dw subtypes correlate with HLA-DR beta and -DQ beta restriction fragment length polymorphisms.
May 1986, Proceedings of the National Academy of Sciences of the United States of America,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
The new HLA-DRw6- and 8- associated HLA-Dw HAG specificity defined by homozygous typing cell 9W 1802. Analysis with primed lymphocyte typing clones.
November 1984, Tissue antigens,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.
February 1986, The Journal of biological chemistry,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
Both HLA-DR and HLA-DQ determinants contribute to HLA-Dw typing.
November 1987, Human immunology,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
HLA-Dw"SHY": a new lymphocyte defined specificity associated with HLA-DRw10.
November 1984, Human immunology,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.
March 1989, The Journal of clinical investigation,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
Polymorphisms within the HLA-DRw6 haplotype. III. DQ alpha and DQ beta polymorphism associated with HLA-D.
June 1987, Human immunology,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
Twenty-six DR beta and 16 DQ beta chain IEF variants and their associated HLA-DR, HLA-DQ, and HLA-Dw specificities.
January 1989, Immunogenetics,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
Determinants not correlated with HLA-Dw, DR, or SB detected by primed lymphocyte typing.
June 1982, Human immunology,
M G Tilanus, and G M Schreuder, and G Pawelec, and M J Giphart
A supertypic HLA-DR specificity (DR4+5) defined by murine monoclonal antibody.
March 1981, Human immunology,
Copied contents to your clipboard!