-transparent.png){kind=logo}
The effect of daily administration of 12 mmol/kg 2,2,4-trimethylpentane for 10 d on hepatic and renal microsomal mono-oxygenase activity, peroxisomal beta-oxidation and the concentration of alpha 2u-globulin has been examined in male and female rats. 2,2,4-Trimethylpentane produces liver and, to a lesser extent, kidney enlargement. This is associated with the selective induction of cytochrome P-450-mediated omega-oxidation and peroxisomal beta-oxidation of fatty acids and proliferation of peroxisomes. Male rats show a more marked response than female rats. 2,2,4-Trimethylpentane produces an increase in alpha 2u-globulin in the kidney of male rats. The relevance of selective induction of omega- and beta-oxidation of fatty acids and accumulation of alpha 2u-globulin to renal tubular necrosis in male rats requires further study.
E A Lock, and
M D Stonard, and
C R Elcombe
March 1987,
Toxicology and applied pharmacology,
E A Lock, and
M D Stonard, and
C R Elcombe
December 1989,
Toxicology and applied pharmacology,
E A Lock, and
M D Stonard, and
C R Elcombe
November 1987,
Toxicology and applied pharmacology,
E A Lock, and
M D Stonard, and
C R Elcombe
March 1989,
FEBS letters,
E A Lock, and
M D Stonard, and
C R Elcombe
November 1986,
The Journal of endocrinology,
E A Lock, and
M D Stonard, and
C R Elcombe
September 1989,
Endocrinology,
E A Lock, and
M D Stonard, and
C R Elcombe
January 1996,
Toxicology,
E A Lock, and
M D Stonard, and
C R Elcombe
October 2014,
Clinical journal of the American Society of Nephrology : CJASN,
E A Lock, and
M D Stonard, and
C R Elcombe
March 1973,
Endocrinology,
E A Lock, and
M D Stonard, and
C R Elcombe
May 1990,
Toxicology and applied pharmacology,
