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Thirty-one granular cell tumors were studied for the presence of myelin basic protein (MBP) using a monoclonal antibody with a characterized specificity and an immunoperoxidase technique. The tumors studied were from all areas of the body, from both sexes, and from nine decades of age. All the tumors stained negatively for MBP. One brief report using a monoclonal antibody had noted positive staining for MBP in granular cell tumors. A more recent study using polyclonal antibodies found negative staining for MBP in Schwann cell neoplasms including granular cell tumors. This study, using an immunohistochemical technique, demonstrated the absence of an MBP marker in granular cell tumors of diverse location despite the fact that granular cell tumors are widely held to be of Schwann cell origin.
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
June 1983,
Archives of pathology & laboratory medicine,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
June 1978,
Journal of neurochemistry,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
March 1993,
Journal of immunology (Baltimore, Md. : 1950),
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
May 1982,
Cancer,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
August 1991,
Immunology today,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
August 1983,
The American journal of pathology,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
January 1982,
Scandinavian journal of immunology. Supplement,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
October 1980,
Biochemical Society transactions,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
January 1981,
Contemporary topics in molecular immunology,
P T Osborne, and
L I Giltman, and
B R Jennings, and
G McClellan
June 1980,
Brain research,
