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Ricin A chain has previously been shown to intoxicate macrophages in vitro following binding and endocytosis by the macrophage mannose receptor. In this report it is demonstrated that the intravenous injection of ricin A chain in nephrectomized rats leads to a prolonged plasma half-life for [125I]beta-glucuronidase, a ligand for the mannose receptor. Clearance of [125I]asialofetuin, a ligand for the galactose receptor of hepatocytes, was unaffected by injection of A chain. Microscopic examination of the livers of A chain-treated animals revealed a loss of phagocytic cells from the liver sinusoids. These results suggest that ricin A chain may be useful as a toxin specific for mannose receptor bearing cells of the reticuloendothelial system.
B M Simmons, and
P D Stahl, and
J H Russell
June 1986,
Biochemical and biophysical research communications,
B M Simmons, and
P D Stahl, and
J H Russell
May 1997,
Carbohydrate research,
B M Simmons, and
P D Stahl, and
J H Russell
May 1993,
The Biochemical journal,
B M Simmons, and
P D Stahl, and
J H Russell
September 1978,
Cell,
B M Simmons, and
P D Stahl, and
J H Russell
April 2001,
Biochimica et biophysica acta,
B M Simmons, and
P D Stahl, and
J H Russell
January 1955,
Experimental medicine and surgery,
B M Simmons, and
P D Stahl, and
J H Russell
December 2016,
Cellular microbiology,
B M Simmons, and
P D Stahl, and
J H Russell
July 1984,
The Journal of cell biology,
B M Simmons, and
P D Stahl, and
J H Russell
June 1977,
The Biochemical journal,
B M Simmons, and
P D Stahl, and
J H Russell
June 2007,
Hepatology (Baltimore, Md.),
