BIOMAT Database Logo BIOMAT Database Logo

Effects of molecular architecture of phospholipid polymers on surface modification of segmented polyurethanes. 2014

Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
a Department of Bioengineering , School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 , Japan.

To modify the surface properties of segmented polyurethane (SPU), effects of the molecular architecture of the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers on the performance of the SPU/MPC polymer membrane were investigated. We combined the random-type, block-type, and graft-type of the MPC polymers with a typical SPU, Tecoflex(®) using double solution casting procedure. The graft-type MPC polymers composed of a poly(MPC) main chain and poly(2-ethylhexyl methacrylate (EHMA)) side chains were synthesized through the combination of two different living radical polymerization techniques to regulate the density and chain length of the side chains. The SPU membranes modified with the MPC polymers were characterized using X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The results revealed that the MPC units were located on the SPU surface. Although the breaking strength of the SPU membranes modified with block-type poly(MPC-block-EHMA) and graft-type poly(MPC-graft-EHMA) was lower than that of SPU membranes modified with random-type poly(MPC-random-EHMA), their breaking strengths were adequate for manufacturing medical devices. On the other hand, better stability was observed in the MPC polymer layer on the SPU membrane after immersion in an aqueous medium, wherein the SPU membrane had been modified with the poly(MPC-graft-EHMA). This was because of the intermixing of the hydrophobic poly(EHMA) segments in the domain of the hard segments in the SPU membrane. After this modification, each SPU/MPC polymer membrane showed hydrophilic nature based on the MPC polymers and a dramatic suppression of protein adsorption. From these results, we concluded that the SPU membrane modified with the poly(MPC-graft-EHMA) was one of the promising polymeric biomaterials for making blood-contacting medical devices.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D008567 Membranes, Artificial Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION. Artificial Membranes,Artificial Membrane,Membrane, Artificial
D008689 Methacrylates Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group. Methacrylate
D010767 Phosphorylcholine Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction. Choline Chloride Dihydrogen Phosphate,Choline Phosphate Chloride,Phosphorylcholine Chloride,Choline Phosphate,Phosphocholine,Chloride, Choline Phosphate,Chloride, Phosphorylcholine,Phosphate Chloride, Choline,Phosphate, Choline
D011109 Polymethacrylic Acids Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer. Methacrylic Acid Polymers,Acid Polymers, Methacrylic,Acids, Polymethacrylic,Polymers, Methacrylic Acid
D011140 Polyurethanes A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams. Polyisocyanates,Ostamer,Pellethane,Spandex,Ostamers,Pellethanes,Polyisocyanate,Polyurethane,Spandices
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D000327 Adsorption The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily. Adsorptions
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001672 Biocompatible Materials Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible

Related Publications

Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Synthesis, characterization and platelet adhesion of segmented polyurethanes grafted phospholipid analogous vinyl monomer on surface.
January 2002, Biomaterials,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Nano-scale surface modification of a segmented polyurethane with a phospholipid polymer.
October 2004, Biomaterials,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
ESCA studies of surface chemical composition of segmented polyurethanes.
March 1979, Journal of biomedical materials research,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Synthesis and surface properties of environmentally responsive segmented polyurethanes.
May 2002, Journal of colloid and interface science,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Effect of surface hydrophilicity on ex vivo blood compatibility of segmented polyurethanes.
April 1991, Biomaterials,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Surface characterization and protein interactions of segmented polyisobutylene-based thermoplastic polyurethanes.
December 2011, Langmuir : the ACS journal of surfaces and colloids,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Effects of molecular architecture of photoreactive phospholipid polymer on adsorption and reaction on substrate surface under aqueous condition.
March 2021, Journal of biomaterials science. Polymer edition,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Use of surface-modifying macromolecules to enhance the biostability of segmented polyurethanes.
June 1997, Journal of biomedical materials research,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Neutrophil-mediated degradation of segmented polyurethanes.
January 1995, Biomaterials,
Yihua Liu, and Yuuki Inoue, and Sho Sakata, and Sachiro Kakinoki, and Tetsuji Yamaoka, and Kazuhiko Ishihara
Surface modification of polymers with self-assembled molecular structures: multitechnique surface characterization.
January 2000, Biomacromolecules,
Copied contents to your clipboard!