Differential effects of paradoxical sleep deprivation on memory and oxidative stress. 2014

Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade Federal do Ceará, R. Cel Nunes de Melo 1315, Rodolfo Teófilo, 60.430-270, Fortaleza, Ceará, Brazil.

Sleep has important functions for every organ in the body and sleep deprivation (SD) leads to disorders that cause irreparable damage. The aim of this study was to investigate behavioral and brain structural alterations in mice deprived of paradoxical sleep for 48 and 72 h. Working memory, aversive memory as well as levels of nitric oxide (NO) and thiobarbituric acid reactive substances (TBARS) in the hippocampus, body striatum, and prefrontal cortex were evaluated. Working memory was affected in the 48- and 72-h SD groups while aversive memory was altered only in the 48-h SD group (p ≤ 0.05). Our findings showed that SD reduces NO levels in most brain areas (p < 0.05): NO levels were unaltered in the striatum of animals sleep-deprived for 48 h. Higher levels of TBARS were observed in all areas of the SD groups (p ≤ 0.05). Thus, we confirmed that SD has duration-dependent effects on behavior as well as on NO and TBARS levels in the brain. Preserved striatum NO levels suggest that this structure is less vulnerable to oxidative stress and is only affected by SD of longer duration. Increased TBARS and reduced NO levels in the hippocampus and prefrontal cortex confirm a central role for both these structures in working memory and aversive memory. Contextual fear conditioning was not affected by longer periods of SD. Thus, our findings suggest that shorter SD time may be more beneficial to avoid aversive memory where this may have implications for the management of posttraumatic stress.

UI MeSH Term Description Entries
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D009569 Nitric Oxide A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Endogenous Nitrate Vasodilator,Mononitrogen Monoxide,Nitric Oxide, Endothelium-Derived,Nitrogen Monoxide,Endothelium-Derived Nitric Oxide,Monoxide, Mononitrogen,Monoxide, Nitrogen,Nitrate Vasodilator, Endogenous,Nitric Oxide, Endothelium Derived,Oxide, Nitric,Vasodilator, Endogenous Nitrate
D009573 Nitrites Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M Nitrite
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012892 Sleep Deprivation The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder. Inadequate Sleep,Insufficient Sleep,Insufficient Sleep Syndrome,REM Sleep Deprivation,Sleep Debt,Sleep Fragmentation,Sleep Insufficiency,Deprivation, REM Sleep,Deprivation, Sleep,Fragmentation, Sleep,Insufficiencies, Sleep,Insufficiency, Sleep,Insufficient Sleep Syndromes,Sleep Deprivation, REM,Sleep Insufficiencies,Sleep, Inadequate,Sleep, Insufficient,Syndrome, Insufficient Sleep
D017392 Thiobarbituric Acid Reactive Substances Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct. TBARs
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018384 Oxidative Stress A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi). Anti-oxidative Stress,Antioxidative Stress,DNA Oxidative Damage,Nitro-Oxidative Stress,Oxidative Cleavage,Oxidative DNA Damage,Oxidative Damage,Oxidative Injury,Oxidative Nitrative Stress,Oxidative Stress Injury,Oxidative and Nitrosative Stress,Stress, Oxidative,Anti oxidative Stress,Anti-oxidative Stresses,Antioxidative Stresses,Cleavage, Oxidative,DNA Damage, Oxidative,DNA Oxidative Damages,Damage, DNA Oxidative,Damage, Oxidative,Damage, Oxidative DNA,Injury, Oxidative,Injury, Oxidative Stress,Nitrative Stress, Oxidative,Nitro Oxidative Stress,Nitro-Oxidative Stresses,Oxidative Cleavages,Oxidative DNA Damages,Oxidative Damage, DNA,Oxidative Damages,Oxidative Injuries,Oxidative Nitrative Stresses,Oxidative Stress Injuries,Oxidative Stresses,Stress Injury, Oxidative,Stress, Anti-oxidative,Stress, Antioxidative,Stress, Nitro-Oxidative,Stress, Oxidative Nitrative,Stresses, Nitro-Oxidative

Related Publications

Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
October 1997, Neuroscience letters,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
March 1979, Activitas nervosa superior,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
April 2020, Physiology & behavior,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
February 2002, Behavioural brain research,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
January 1970, Journal de physiologie,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
June 1994, Physiology & behavior,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
April 2021, Journal of basic and clinical physiology and pharmacology,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
November 1984, Physiology & behavior,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
April 1977, Archives internationales de physiologie et de biochimie,
Alisson Menezes Araujo Lima, and Veralice Meireles Sales de Bruin, and Emiliano Ricardo Vasconcelos Rios, and Pedro Felipe Carvalhedo de Bruin
January 1982, Biological psychology,
Copied contents to your clipboard!