-transparent.png){kind=logo}
The effect of milrinone on mechanical function was studied in the isolated arterially perfused heart of the fetal (28th day of gestation) and newborn rabbits. The inotropic effect of milrinone in the fetus was significantly less than in the newborn. After milrinone infusion, myocardial cyclic AMP levels increased significantly in the two age groups and the fetal values before and after milrinone infusion were not significantly different from the newborn values. In our previous study the inotropic effects of dibutyryl cyclic AMP and high extracellular calcium in the fetus were significantly less than in the newborn. These data suggest that the diminished inotropic effect of milrinone in the fetus may be due, at least in part, to the decreased inotropism of cyclic AMP and calcium.
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
February 1987,
Journal of molecular and cellular cardiology,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
June 1997,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
January 1986,
The Journal of pharmacology and experimental therapeutics,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
January 1984,
Developmental pharmacology and therapeutics,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
January 1982,
Developmental pharmacology and therapeutics,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
January 1987,
Journal of ocular pharmacology,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
December 1994,
European heart journal,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
January 1979,
Texas reports on biology and medicine,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
November 1980,
Experientia,
S Ogawa, and
T Nakanishi, and
K Kamata, and
A Takao
January 1973,
Recent advances in studies on cardiac structure and metabolism,
