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Serotonin (5-HT)-immunoreactive innervation can be demonstrated in both the pars intermedia and pars nervosa of the rat pituitary gland. Fluoxetine hydrochloride, a 5-HT uptake inhibitor, was administered in single or multiple doses to adult male Sprague-Dawley rats to examine the possibility that 5-HT present in pituitary fibers may be due to uptake of the indoleamine. Paraffin-embedded sections of pituitaries from fluoxetine-treated rats revealed diminution or loss of 5-HT fiber staining in the intermediate, but not in the neural lobe, in all animals examined. Multiple doses of fluoxetine produced the most consistent effects on immunostaining. These observations along with results of our previous studies suggest that the intermediate lobe innervation immunoreactive for 5-HT may be due to uptake of indoleamine from extrinsic sources, while the pars nervosa terminals containing 5-HT most likely originate from 5-HT neuronal perikarya in the lower brainstem or hypothalamus.
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
July 1983,
European journal of pharmacology,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
April 1978,
Clinical pharmacology and therapeutics,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
January 1991,
Medicinal research reviews,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
January 1985,
Journal of neural transmission,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
May 1999,
Cell and tissue research,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
June 1980,
Endocrinology,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
January 1990,
International clinical psychopharmacology,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
April 1996,
Neuroscience letters,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
August 1979,
Life sciences,
L C Saland, and
J A Wallace, and
E Reyes, and
A Samora, and
D Maez, and
F Comunas
January 1988,
Psychopharmacology,
