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We studied polymorphonuclear leukocyte (PMNL) chemotaxis in 3 patients with generalized pustular psoriasis using 3 chemoattractants: Zymosan-activated serum from both the patients and normal individuals, and n-formyl-methionyl-leucyl-phenylalanine (FMLP). These attractants were assayed against both patient-derived and normal PMNLs. All patients had quiescent skin disease at the time of assay. We found that all patients had decreased PMNL chemotaxis to autologous Zymosan-activated serum, but not to FMLP. PMNLs from normal individuals responded normally to serum from the patients. We conclude that patients with generalized pustular psoriasis, when free of symptoms, may have an isolated PMNL chemotactic defect that is restricted to serum-derived attractants.
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M R Pittelkow, and
S A Muller, and
C M Johnson
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B D Zelickson, and
M R Pittelkow, and
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C M Johnson
July 1983,
The British journal of dermatology,
B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
November 1980,
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B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
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B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
June 1964,
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B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
January 1953,
Bulletin de la Societe francaise de dermatologie et de syphiligraphie,
B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
March 1973,
The Medical journal of Australia,
B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
October 1972,
Archives of dermatology,
B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
October 1979,
Archives of dermatology,
B D Zelickson, and
M R Pittelkow, and
S A Muller, and
C M Johnson
March 1972,
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