Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function. 2014

Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear. This study found that PTX3 expression was up-regulated in distant bone metastases of breast cancer compared to lung, liver, and brain metastases in 64 human breast cancer patients. Elevated expression of PTX3 was correlated with poor survival in patients with breast cancer. PTX3 expression was also up-regulated in a bone metastatic breast cancer cell line and further enhanced by pro-inflammatory cytokine TNFα. Administration of PTX3 promoted the migratory potential of breast cancer cells and the mobilization of macrophages, a precursor of osteoclasts (OCs), toward breast cancer cells. In addition, elevated expression of PTX3 by TNFα led to enhanced OC formation, implying the distinct role of PTX3 in osteolytic bone metastasis of breast cancer cells. Furthermore, PTX3 silencing using PTX3-specific siRNA prevented breast cancer cell migration, macrophage chemotaxis, and subsequent OC formation. These findings provide an important insight into the key role of PTX3 in inflammation-associated osteolytic complications of breast cancer.

UI MeSH Term Description Entries
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D010010 Osteoclasts A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption. Odontoclasts,Cementoclast,Cementoclasts,Odontoclast,Osteoclast
D001859 Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES. Bone Cancer,Cancer of Bone,Cancer of the Bone,Neoplasms, Bone,Bone Neoplasm,Neoplasm, Bone
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002097 C-Reactive Protein A plasma protein that circulates in increased amounts during inflammation and after tissue damage. C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). High Sensitivity C-Reactive Protein,hs-CRP,hsCRP,C Reactive Protein,High Sensitivity C Reactive Protein
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000683 Serum Amyloid P-Component Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE. Amyloid P Component,Amyloid P-Component, Serum,P Component, Amyloid,P-Component, Serum Amyloid,Serum Amyloid P Component
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
March 2013, Asian journal of andrology,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
January 1994, Breast cancer research and treatment,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
November 2016, Clinica chimica acta; international journal of clinical chemistry,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
January 2021, Mediterranean journal of hematology and infectious diseases,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
June 1950, The American journal of medicine,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
August 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
June 2013, Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
January 2022, Journal of immunotherapy (Hagerstown, Md. : 1997),
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
November 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
Bongkun Choi, and Eun-Jin Lee, and Da-Hyun Song, and Sung-Chul Yoon, and Yeon-Ho Chung, and Youngsaeng Jang, and Sang-Min Kim, and Youngsup Song, and Sang-Wook Kang, and Seung-Yong Yoon, and Eun-Ju Chang
September 2006, Bulletin du cancer,
Copied contents to your clipboard!