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The effects of high fat diet and injection of chlorpromazine on bile lipid secretion were studied in the rats fed a control diet (C), a saturated fat, high cholesterol diet (S) and a polyunsaturated fat, high cholesterol diet (PU). As compared to controls, injection of chlorpromazine in the S and PU diet groups caused no appreciable change in the level of bile salts and bile phospholipids. Chlorpromazine did however enhance bile cholesterol, especially in the PU group, and lower secretion of lysosomal enzyme (beta-glucuronidase) into bile. Impairment of lysosomal enzyme secretion but not of bile lipid secretion suggests that the lysosomal activity is not directly involved in the bile secretion mechanism. These data point up the risks of using chlorpromazine therapy in association with a diet high in fat and cholesterol.
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
October 2019,
Clinical nutrition research,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
November 2009,
Wei sheng yan jiu = Journal of hygiene research,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
January 1994,
Advances in experimental medicine and biology,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
December 2010,
Biological trace element research,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
November 1974,
Experientia,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
January 2008,
Nutrition research and practice,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
April 1982,
Atherosclerosis,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
December 2012,
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
January 1993,
Nutrition and cancer,
H Lafont, and
F Chanussot, and
D Lairon, and
C Chabert, and
N Domingo, and
H Portugal, and
A M Pauli, and
J C Hauton
November 2005,
Physiology & behavior,
