Biomaterial Database

Calcitonin gene-related peptide but not substance P mimics capsaicin-induced coronary vasodilation in the pig. 1987

A Franco-Cereceda, and A Rudehill, and J M Lundberg

Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.

The vasodilator effects of the human calcitonin gene-related peptides alpha (hCGRP alpha) and beta (hCGRP beta) were studied in vitro and in vivo in relation to the effects of substance P (SP) and capsaicin on coronary vascular tone in the pig. Both hCGRP alpha and -beta induced a concentration-dependent, long-lasting relaxation of precontracted small (diameter 0.5 mm) pig coronary arteries in vitro. SP was slightly more potent but caused a transient relaxation with a smaller maximal response than CGRP. The relaxation induced by hCGRP alpha and -beta as well as SP was resistant to propranolol and atropine. Capsaicin also induced a long-lasting relaxation of potassium and PGF2 alpha-precontracted coronary arteries. After tachyphylaxis to SP had developed the relaxant effects of CGRP and capsaicin were unchanged. Rubbing the vessels to remove the endothelium completely abolished the relaxant effects of SP while the vasodilation induced by hCGRP alpha as well as capsaicin remained unchanged. Injections of hCGRP alpha, SP or capsaicin into the constantly perfused left anterior descending coronary artery of the pig in vivo caused a dose-dependent decrease in perfusion pressure, suggesting coronary vasodilation. In conclusion, the vasodilator effects of SP in vitro differ from the response to CGRP both with regard to their transient nature, the development of tachyphylaxis and endothelium dependence. The capsaicin-induced coronary vasodilation is therefore more likely to depend on release of CGRP rather than tachykinins from sensory nerves since neither endothelium removal nor SP-tachyphylaxis influenced the capsaicin and CGRP responses.(ABSTRACT TRUNCATED AT 250 WORDS)

UI	MeSH Term	Description	Entries
D009479	Neuropeptides	Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells.	Neuropeptide
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002211	Capsaicin	An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.	8-Methyl-N-Vanillyl-6-Nonenamide,Antiphlogistine Rub A-535 Capsaicin,Axsain,Capsaicine,Capsicum Farmaya,Capsidol,Capsin,Capzasin,Gelcen,Katrum,NGX-4010,Zacin,Zostrix,8 Methyl N Vanillyl 6 Nonenamide,NGX 4010,NGX4010
D003331	Coronary Vessels	The veins and arteries of the HEART.	Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004730	Endothelium, Vascular	Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.	Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D006439	Hemodynamics	The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.	Hemodynamic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013373	Substance P	An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.	Euler-Gaddum Substance P,Hypothalamic Substance P,SP(1-11),Euler Gaddum Substance P,Substance P, Euler-Gaddum,Substance P, Hypothalamic
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014664	Vasodilation	The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.	Vasodilatation,Vasorelaxation,Vascular Endothelium-Dependent Relaxation,Endothelium-Dependent Relaxation, Vascular,Relaxation, Vascular Endothelium-Dependent,Vascular Endothelium Dependent Relaxation