Biomaterial Database

Behavioral interaction between endogenous opioids, CCK-8 and dopaminergic systems in the nucleus accumbens of rats. 1986

J M van Ree, and J Igarashi, and I Király

Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, The Netherlands.

Injection of apomorphine into the nucleus accumbens of rats elicits hypermotility, presumably by activating postsynaptically located dopamine receptor systems. This behavioral response is inhibited by local treatment with CCK-8 or gamma-endorphin. The action of both peptides is antagonized by intra-accumbal treatment with naloxone. These findings suggest that endogenous opioids are implicated in certain neuroleptic-like effects of CCK-8 and that in the nucleus accumbens a functional interaction exists between CCK-8, endogenous opioids and dopaminergic systems.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D009270	Naloxone	A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.	MRZ 2593-Br,MRZ-2593,Nalone,Naloxon Curamed,Naloxon-Ratiopharm,Naloxone Abello,Naloxone Hydrobromide,Naloxone Hydrochloride,Naloxone Hydrochloride Dihydride,Naloxone Hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer,Narcan,Narcanti,Abello, Naloxone,Curamed, Naloxon,Dihydride, Naloxone Hydrochloride,Hydrobromide, Naloxone,Hydrochloride Dihydride, Naloxone,Hydrochloride, Naloxone,MRZ 2593,MRZ 2593 Br,MRZ 2593Br,MRZ2593,Naloxon Ratiopharm
D009714	Nucleus Accumbens	Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.	Accumbens Nucleus,Nucleus Accumbens Septi,Accumbens Septi, Nucleus,Accumbens Septus, Nucleus,Accumbens, Nucleus,Nucleus Accumbens Septus,Nucleus, Accumbens,Septi, Nucleus Accumbens,Septus, Nucleus Accumbens
D011919	Rats, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.	August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D004723	Endorphins	One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.	Endorphin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001058	Apomorphine	A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	Apokinon,Apomorphin-Teclapharm,Apomorphine Chloride,Apomorphine Hydrochloride,Apomorphine Hydrochloride Anhydrous,Apomorphine Hydrochloride, Anhydrous,Apomorphine Hydrochloride, Hemihydrate,Britaject,Apomorphin Teclapharm
D012686	Septal Nuclei	Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of FOREBRAIN and BRAIN STEM areas including the HIPPOCAMPAL FORMATION, the LATERAL HYPOTHALAMUS, the tegmentum, and the AMYGDALA. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.	Bed Nucleus of Stria Terminalis,Nucleus of Anterior Commissure,Nucleus of Diagonal Band,Nucleus of Stria Terminalis,Septofimbrial Nucleus,Dorsal Septal Nucleus,Lateral Septal Nucleus,Lateral Septum Nucleus,Medial Septal Nucleus,Medial Septum Nucleus,Nucleus Interstitialis Striae Terminalis,Nucleus Lateralis Septi,Nucleus Septalis Lateralis,Nucleus Septi Lateralis,Nucleus Striae Terminalis,Nucleus Triangularis Septi,Nucleus of the Stria Terminalis,Septal Nuclear Complex,Triangular Septal Nucleus,Anterior Commissure Nucleus,Complex, Septal Nuclear,Complices, Septal Nuclear,Diagonal Band Nucleus,Laterali, Nucleus Septalis,Laterali, Nucleus Septi,Lateralis Septi, Nucleus,Lateralis Septus, Nucleus,Lateralis, Nucleus Septalis,Lateralis, Nucleus Septi,Nuclear Complex, Septal,Nuclear Complices, Septal,Nuclei, Septal,Nucleus Lateralis Septus,Nucleus Septalis Laterali,Nucleus Septi Laterali,Nucleus Striae Terminali,Nucleus Triangularis Septus,Nucleus, Dorsal Septal,Nucleus, Lateral Septal,Nucleus, Lateral Septum,Nucleus, Medial Septal,Nucleus, Medial Septum,Nucleus, Septofimbrial,Nucleus, Triangular Septal,Septal Nuclear Complices,Septal Nucleus, Dorsal,Septal Nucleus, Lateral,Septal Nucleus, Medial,Septal Nucleus, Triangular,Septalis Laterali, Nucleus,Septalis Lateralis, Nucleus,Septi Laterali, Nucleus,Septi Lateralis, Nucleus,Septi, Nucleus Lateralis,Septi, Nucleus Triangularis,Septum Nucleus, Lateral,Septum Nucleus, Medial,Septus, Nucleus Lateralis,Septus, Nucleus Triangularis,Stria Terminalis Nucleus,Striae Terminali, Nucleus,Striae Terminalis, Nucleus,Terminali, Nucleus Striae,Terminalis, Nucleus Striae,Triangularis Septi, Nucleus,Triangularis Septus, Nucleus