BIOMAT Database Logo BIOMAT Database Logo

Copper-catalyzed ortho-C-H amination of protected anilines with secondary amines. 2014

Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. n.rodriguez@uam.es ramon.gomez@uam.es.

A practical Cu-catalyzed picolinamide-directed o-amination of anilines showing excellent mono-substitution selectivity and high functional group tolerance has been developed.

UI MeSH Term Description Entries
D002244 Carbon A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel. Carbon-12,Vitreous Carbon,Carbon 12,Carbon, Vitreous
D002384 Catalysis The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction. Catalyses
D003300 Copper A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55. Copper-63,Copper 63
D006859 Hydrogen The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas. Protium,Hydrogen-1
D000586 Amination The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group. Aminations
D000588 Amines A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amine
D000814 Aniline Compounds Compounds that include the aminobenzene structure. Phenylamine,Phenylamines,Anilines,Compounds, Aniline

Related Publications

Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines.
July 2020, Organic letters,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Copper-Catalyzed Electrochemical C-H Amination of Arenes with Secondary Amines.
September 2018, Journal of the American Chemical Society,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Ligand-Promoted Rhodium(III)-Catalyzed ortho-C-H Amination with Free Amines.
June 2017, Angewandte Chemie (International ed. in English),
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Copper-Catalyzed Electrophilic Ortho C(sp2)-H Amination of Aryl Amines: Dramatic Reactivity of Bicyclic System.
June 2019, Organic letters,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Nickel-catalyzed C-H direct amination of benzoxazoles with secondary amines.
May 2012, Organic & biomolecular chemistry,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Copper-Catalyzed Intramolecular Amination of C(sp3)-H Bond of Secondary Amines to Access Azacycles.
January 2021, Organic letters,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Copper-catalyzed carboxamide-directed ortho amination of anilines with alkylamines at room temperature.
March 2014, Organic letters,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Copper-catalyzed direct oxidative C-H amination of benzoxazoles with formamides or secondary amines under mild conditions.
July 2011, The Journal of organic chemistry,
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
Beyond Tertiary Amines: Introducing Secondary Amines via Palladium/Norbornene-Catalyzed Ortho Amination.
April 2024, Angewandte Chemie (International ed. in English),
Ángel Manu Martínez, and Nuria Rodríguez, and Ramón Gómez Arrayás, and Juan C Carretero
De novo synthesis of Troc-protected amines: intermolecular rhodium-catalyzed C-H amination with N-tosyloxycarbamates.
February 2007, Organic letters,
Copied contents to your clipboard!